supplement evidence

Vitamin K Bone Meta-Analysis Evidence Table

Structured evidence table for Vitamin K Bone Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Vitamin K Bone Meta-AnalysisThe same vascular calcification that stiffens large arteries and elevates cardiovascular risk also compromises the cerebral microvasculature that sustains neuronal metabolism, and reflects a systemic mishandling of calcium that is associated with depletion of the skeletal reservoir [,].3Fang Shih-Chin (2026)Beyond Bone Health: Exploring the “Heart–Brain–Bone” Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2)
Vitamin K Bone Meta-AnalysisFirst, we set out the review methodology, including the search strategy, eligibility criteria, and the explicit framework used to grade the strength of evidence ().3Fang Shih-Chin (2026)Beyond Bone Health: Exploring the “Heart–Brain–Bone” Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2)
Vitamin K Bone Meta-AnalysisThird, we critically appraise the clinical trial evidence, explicitly distinguishing mechanistic, observational, and randomized data and presenting positive, neutral, and null findings alongside one another; delineate the controversies and unresolved questions that temper any therapeutic claim; and identify the populations in which supplementation is most plausibly warranted (,and).3Fang Shih-Chin (2026)Beyond Bone Health: Exploring the “Heart–Brain–Bone” Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2)
Vitamin K Bone Meta-AnalysisPopulation aging is among the most consequential epidemiological transitions of the twenty-first century, and it is accompanied by a parallel rise in chronic, degenerative, non-communicable diseases.3Fang Shih-Chin (2026)Beyond Bone Health: Exploring the “Heart–Brain–Bone” Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2)
Vitamin K Bone Meta-AnalysisEditorial: Natural products in bone health and disease: mechanisms, therapeutics, and clinical potential.4Chin KY (2026)Editorial: Natural products in bone health and disease: mechanisms, therapeutics, and clinical potential.
topicVitamin K Bone Meta-Analysis
claimThe same vascular calcification that stiffens large arteries and elevates cardiovascular risk also compromises the cerebral microvasculature that sustains neuronal metabolism, and reflects a systemic mishandling of calcium that is associated with depletion of the skeletal reservoir [,].
evidence level3
citationFang Shih-Chin (2026)
sourceBeyond Bone Health: Exploring the “Heart–Brain–Bone” Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2)
topicVitamin K Bone Meta-Analysis
claimFirst, we set out the review methodology, including the search strategy, eligibility criteria, and the explicit framework used to grade the strength of evidence ().
evidence level3
citationFang Shih-Chin (2026)
sourceBeyond Bone Health: Exploring the “Heart–Brain–Bone” Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2)
topicVitamin K Bone Meta-Analysis
claimThird, we critically appraise the clinical trial evidence, explicitly distinguishing mechanistic, observational, and randomized data and presenting positive, neutral, and null findings alongside one another; delineate the controversies and unresolved questions that temper any therapeutic claim; and identify the populations in which supplementation is most plausibly warranted (,and).
evidence level3
citationFang Shih-Chin (2026)
sourceBeyond Bone Health: Exploring the “Heart–Brain–Bone” Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2)
topicVitamin K Bone Meta-Analysis
claimPopulation aging is among the most consequential epidemiological transitions of the twenty-first century, and it is accompanied by a parallel rise in chronic, degenerative, non-communicable diseases.
evidence level3
citationFang Shih-Chin (2026)
sourceBeyond Bone Health: Exploring the “Heart–Brain–Bone” Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2)
topicVitamin K Bone Meta-Analysis
claimEditorial: Natural products in bone health and disease: mechanisms, therapeutics, and clinical potential.
evidence level4
citationChin KY (2026)
sourceEditorial: Natural products in bone health and disease: mechanisms, therapeutics, and clinical potential.

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Source documents

  1. Beyond Bone Health: Exploring the “Heart–Brain–Bone” Axis Modulated by Lipid-Soluble Nutrients (Omega-3, Vitamin D3, and Vitamin K2)
  2. Editorial: Natural products in bone health and disease: mechanisms, therapeutics, and clinical potential.