supplement evidence

Vitamin B6 Mood Randomized Trial Evidence Table

Structured evidence table for Vitamin B6 Mood Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Vitamin B6 Mood Randomized TrialBackground Several lines of evidence suggest that vitamin B6 has potential as an antidepressant.4Field DT (2026)High Dose Vitamin B6 Reduces Depression Symptoms.
Vitamin B6 Mood Randomized TrialFurthermore, epidemiological evidence points to vitamin B6 deficiency as a risk factor for depression, and to high vitamin B6 levels as protective.4Field DT (2026)High Dose Vitamin B6 Reduces Depression Symptoms.
Vitamin B6 Mood Randomized TrialWe also found evidence that participants whose DASS depression scores narrowly failed to meet criterion for moderate depression ( N = 52) experienced a slightly smaller but still statistically substantial reduction in symptoms (partial η 2 = 0.17).4Field DT (2026)High Dose Vitamin B6 Reduces Depression Symptoms.
Vitamin B6 Mood Randomized TrialIt plays a crucial coenzyme role in the synthesis of the neurotransmitters serotonin, gamma-aminobutyric acid (GABA) and dopamine, which are central to mood regulation, and it has been shown that increasing availably of vitamin B6 above normal levels increases concentrations of serotonin and GABA.4Field DT (2026)High Dose Vitamin B6 Reduces Depression Symptoms.
Vitamin B6 Mood Randomized TrialBackground: A nutritional supplement based on medicinal plants (saffron and ashwagandha), tryptophan, and vitamin B6 could contribute to alleviating/improving mood and associated disorders.4Pages-García C (2024)Effectiveness of a Saffron and Withania Supplement on Mood in Women With Mild-to-Moderate Anxiety During the COVID-19 Lockdown.
Vitamin B6 Mood Randomized TrialHowever, no significant changes were found during the lockdown period (between weeks 8 and 12 of the study).4Pages-García C (2024)Effectiveness of a Saffron and Withania Supplement on Mood in Women With Mild-to-Moderate Anxiety During the COVID-19 Lockdown.
Vitamin B6 Mood Randomized TrialNo relationship was found between women's sociodemographic characteristics and the HARS total score.4Pages-García C (2024)Effectiveness of a Saffron and Withania Supplement on Mood in Women With Mild-to-Moderate Anxiety During the COVID-19 Lockdown.
Vitamin B6 Mood Randomized TrialThe aim of this study was to evaluate the potential benefits of this combination supplement.4Pages-García C (2024)Effectiveness of a Saffron and Withania Supplement on Mood in Women With Mild-to-Moderate Anxiety During the COVID-19 Lockdown.
topicVitamin B6 Mood Randomized Trial
claimBackground Several lines of evidence suggest that vitamin B6 has potential as an antidepressant.
evidence level4
citationField DT (2026)
sourceHigh Dose Vitamin B6 Reduces Depression Symptoms.
topicVitamin B6 Mood Randomized Trial
claimFurthermore, epidemiological evidence points to vitamin B6 deficiency as a risk factor for depression, and to high vitamin B6 levels as protective.
evidence level4
citationField DT (2026)
sourceHigh Dose Vitamin B6 Reduces Depression Symptoms.
topicVitamin B6 Mood Randomized Trial
claimWe also found evidence that participants whose DASS depression scores narrowly failed to meet criterion for moderate depression ( N = 52) experienced a slightly smaller but still statistically substantial reduction in symptoms (partial η 2 = 0.17).
evidence level4
citationField DT (2026)
sourceHigh Dose Vitamin B6 Reduces Depression Symptoms.
topicVitamin B6 Mood Randomized Trial
claimIt plays a crucial coenzyme role in the synthesis of the neurotransmitters serotonin, gamma-aminobutyric acid (GABA) and dopamine, which are central to mood regulation, and it has been shown that increasing availably of vitamin B6 above normal levels increases concentrations of serotonin and GABA.
evidence level4
citationField DT (2026)
sourceHigh Dose Vitamin B6 Reduces Depression Symptoms.
topicVitamin B6 Mood Randomized Trial
claimBackground: A nutritional supplement based on medicinal plants (saffron and ashwagandha), tryptophan, and vitamin B6 could contribute to alleviating/improving mood and associated disorders.
evidence level4
citationPages-García C (2024)
sourceEffectiveness of a Saffron and Withania Supplement on Mood in Women With Mild-to-Moderate Anxiety During the COVID-19 Lockdown.
topicVitamin B6 Mood Randomized Trial
claimHowever, no significant changes were found during the lockdown period (between weeks 8 and 12 of the study).
evidence level4
citationPages-García C (2024)
sourceEffectiveness of a Saffron and Withania Supplement on Mood in Women With Mild-to-Moderate Anxiety During the COVID-19 Lockdown.
topicVitamin B6 Mood Randomized Trial
claimNo relationship was found between women's sociodemographic characteristics and the HARS total score.
evidence level4
citationPages-García C (2024)
sourceEffectiveness of a Saffron and Withania Supplement on Mood in Women With Mild-to-Moderate Anxiety During the COVID-19 Lockdown.
topicVitamin B6 Mood Randomized Trial
claimThe aim of this study was to evaluate the potential benefits of this combination supplement.
evidence level4
citationPages-García C (2024)
sourceEffectiveness of a Saffron and Withania Supplement on Mood in Women With Mild-to-Moderate Anxiety During the COVID-19 Lockdown.

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Source documents

  1. High Dose Vitamin B6 Reduces Depression Symptoms.
  2. Effectiveness of a Saffron and Withania Supplement on Mood in Women With Mild-to-Moderate Anxiety During the COVID-19 Lockdown.