Valerian Sleep Onset Randomized Trial Evidence Table

Structured evidence table for Valerian Sleep Onset Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Valerian Sleep Onset Randomized TrialThis narrative review critically evaluates clinical evidence on commonly used herbal preparations, with particular emphasis on herb-drug interactions, adverse effects, and issues related to product adulteration.3Căuș MN (2026)Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
Valerian Sleep Onset Randomized TrialHowever, clinically relevant risks were identified, including cytochrome P450-mediated drug interactions, excessive sedation, serotonin syndrome, and toxic effects associated with adulterated products, such as hepatotoxicity, cardiovascular events, and neurological disturbances.3Căuș MN (2026)Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
Valerian Sleep Onset Randomized TrialIncreased awareness of herb-drug interactions and stricter quality control are essential to optimize therapeutic outcomes and minimize harm.3Căuș MN (2026)Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
Valerian Sleep Onset Randomized TrialBackground/Objectives: Plant-based supplements are widely used for the management of anxiety, depression, and insomnia.3Căuș MN (2026)Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
Valerian Sleep Onset Randomized TrialFailure to meet the recommended 7-9 hours of restful sleep per night is known to increase the risk of several health conditions, reason why regular and adequate sleep should be seen as a priority instead of an unnecessary commodity easily traded as required by the commitments of our busy lives.4Conti F (2026)Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
Valerian Sleep Onset Randomized TrialWhile both the quantity and the quality of sleep can be largely improved with relatively straightforward practices dictated by good sleep hygiene, emerging research suggests that dietary and supplementation protocols focused on certain foods, nutrients, and biochemical compounds with sleep-promoting properties can act as subsidiary sleep aids in complementing these behavioral changes.4Conti F (2026)Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
Valerian Sleep Onset Randomized TrialThe scope of this narrative review is to summarize the available evidence on the potential benefits of selected nutraceuticals in the context of circadian rhythm and sleep disturbances, namely melatonin, magnesium, omega-3 fatty acids, tart cherry juice, kiwifruit, apigenin, valerian root, L-theanine, glycine, ashwagandha, myoinositol, Rhodiola rosea, and phosphatidylserine.4Conti F (2026)Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
Valerian Sleep Onset Randomized TrialHumans spend approximately one third of their life asleep but, as counterintuitive as it may sound, sleep is far from being a quiet state of inactivity.4Conti F (2026)Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
topicValerian Sleep Onset Randomized Trial
claimThis narrative review critically evaluates clinical evidence on commonly used herbal preparations, with particular emphasis on herb-drug interactions, adverse effects, and issues related to product adulteration.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
topicValerian Sleep Onset Randomized Trial
claimHowever, clinically relevant risks were identified, including cytochrome P450-mediated drug interactions, excessive sedation, serotonin syndrome, and toxic effects associated with adulterated products, such as hepatotoxicity, cardiovascular events, and neurological disturbances.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
topicValerian Sleep Onset Randomized Trial
claimIncreased awareness of herb-drug interactions and stricter quality control are essential to optimize therapeutic outcomes and minimize harm.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
topicValerian Sleep Onset Randomized Trial
claimBackground/Objectives: Plant-based supplements are widely used for the management of anxiety, depression, and insomnia.
evidence level3
citationCăuș MN (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
topicValerian Sleep Onset Randomized Trial
claimFailure to meet the recommended 7-9 hours of restful sleep per night is known to increase the risk of several health conditions, reason why regular and adequate sleep should be seen as a priority instead of an unnecessary commodity easily traded as required by the commitments of our busy lives.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
topicValerian Sleep Onset Randomized Trial
claimWhile both the quantity and the quality of sleep can be largely improved with relatively straightforward practices dictated by good sleep hygiene, emerging research suggests that dietary and supplementation protocols focused on certain foods, nutrients, and biochemical compounds with sleep-promoting properties can act as subsidiary sleep aids in complementing these behavioral changes.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
topicValerian Sleep Onset Randomized Trial
claimThe scope of this narrative review is to summarize the available evidence on the potential benefits of selected nutraceuticals in the context of circadian rhythm and sleep disturbances, namely melatonin, magnesium, omega-3 fatty acids, tart cherry juice, kiwifruit, apigenin, valerian root, L-theanine, glycine, ashwagandha, myoinositol, Rhodiola rosea, and phosphatidylserine.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.
topicValerian Sleep Onset Randomized Trial
claimHumans spend approximately one third of their life asleep but, as counterintuitive as it may sound, sleep is far from being a quiet state of inactivity.
evidence level4
citationConti F (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.

Source documents

  1. Efficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks.
  2. Dietary Protocols to Promote and Improve Restful Sleep: A Narrative Review.