Structured evidence table for Urolithin-A Sleep Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Urolithin-A Sleep Randomized Trial | Polyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ). | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Urolithin-A Sleep Randomized Trial | While many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Urolithin-A Sleep Randomized Trial | Controlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Urolithin-A Sleep Randomized Trial | AMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Urolithin-A Sleep Randomized Trial | Wukich and colleagues established that diabetes adversely affects outcomes across all orthopedic subspecialties, including increased surgical site infections, delayed wound healing, and impaired bone consolidation []. | 4 | Santos Márcia da Silva (2026) | Nutritional Interventions to Optimize Orthobiologic Therapy Quality in Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Framework: A Narrative Review |
| Urolithin-A Sleep Randomized Trial | Meta-analytic evidence demonstrates that diabetic patients have an odds ratio of 2.11 for impaired fracture healing compared to non-diabetic individuals [], while tendinopathy prevalence is markedly elevated, with 27.5% of diabetic patients experiencing shoulder disorders compared to 5% in the general population [,]. | 4 | Santos Márcia da Silva (2026) | Nutritional Interventions to Optimize Orthobiologic Therapy Quality in Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Framework: A Narrative Review |
| Urolithin-A Sleep Randomized Trial | A notable 19-year follow-up study confirmed a persistent increased risk of tendon injury in patients with structured diabetes care. | 4 | Santos Márcia da Silva (2026) | Nutritional Interventions to Optimize Orthobiologic Therapy Quality in Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Framework: A Narrative Review |
| Urolithin-A Sleep Randomized Trial | 1 2 3 4 Type 2 diabetes mellitus (T2DM) has reached pandemic proportions, affecting over 537 million adults globally, with projections indicating 783 million by 2045 []. | 4 | Santos Márcia da Silva (2026) | Nutritional Interventions to Optimize Orthobiologic Therapy Quality in Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Framework: A Narrative Review |
Source documents