topicTyrosine Cognitive Performance Randomized Trial
claimEmerging empirical evidence indicates that a simultaneous approach targeting mitochondrial function, one-carbon metabolism, and catecholaminergic pathways may yield a more efficacious strategy than isolated interventions ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicTyrosine Cognitive Performance Randomized Trial
claimThe dysregulation of methylation pathways has been associated with the onset of metabolic syndrome, cognitive decline, and muscular dysfunction ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicTyrosine Cognitive Performance Randomized Trial
claimThe process of aging, along with metabolic disorders, is often correlated with compromised dopaminergic signaling, which contributes to diminished physical performance and increased levels of fatigue.
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicTyrosine Cognitive Performance Randomized Trial
claim1 2 3 4 5 6 7 8 9 Athletic performance represents a multifaceted phenotype influenced by the interplay of mitochondrial bioenergetics, epigenetic modulation, and neurotransmitter signaling ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicTyrosine Cognitive Performance Randomized Trial
claimβ 6 7 8 9 10 L-Carnosine (L-CAR) is a dipeptide composed of-alanine and histidine, predominantly found in fast-twitch muscle fibers.
evidence level4
citationBilgin Süleyman (2026)
sourceCombined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players
topicTyrosine Cognitive Performance Randomized Trial
claim5 6 9 10 11 12 16 17 Although various ergogenic strategies have been developed to support these complex requirements (), evidence examining their simultaneous effects on both physical and cognitive performance remains limited.
evidence level4
citationBilgin Süleyman (2026)
sourceCombined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players
topicTyrosine Cognitive Performance Randomized Trial
claimL-TYR was administered at a dose of 150 mg/kg body weight, in line with studies reporting improved cognitive performance and stress resilience in high-demand conditions (,).
evidence level4
citationBilgin Süleyman (2026)
sourceCombined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players
topicTyrosine Cognitive Performance Randomized Trial
claim1–3 4 5 Football is a multifaceted, intermittent team sport that places high physiological and cognitive demands on athletes.
evidence level4
citationBilgin Süleyman (2026)
sourceCombined L-carnosine and L-tyrosine supplementation as an ergogenic strategy for physical and cognitive performance under fatigue in professional football players