topicTocotrienols Cognitive Performance Meta-Analysis
claim1 2 3 4 5 6 In the general population, subjective memory complaints (SMC) are associated with a reduced global quality of life, increased risk of depression, and negative impact on daily living activities (,).
evidence level2
citationLopresti Adrian L. (2025)
sourceAn examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial
topicTocotrienols Cognitive Performance Meta-Analysis
claimResearch also suggests that SMC in middle age is a concern as it is associated with cortical thinning in brain regions affected by Alzheimer’s disease (AD) and poorer performance on objective memory tests ().
evidence level2
citationLopresti Adrian L. (2025)
sourceAn examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial
topicTocotrienols Cognitive Performance Meta-Analysis
claimMemory complaints are distressing for adults of all ages and are associated with greater negative affect (,).
evidence level2
citationLopresti Adrian L. (2025)
sourceAn examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial
topicTocotrienols Cognitive Performance Meta-Analysis
claimOlder people with SMC are twice as likely to develop dementia compared to individuals without SMC.
evidence level2
citationLopresti Adrian L. (2025)
sourceAn examination into the effects of tocotrienols (TheraPrimE® rice) on cognitive abilities and sleep in healthy adults: a randomised, double-blind, placebo-controlled trial
topicTocotrienols Cognitive Performance Meta-Analysis
claimThis review summarizes current evidence on nutritional compounds that target aging-related pathways, focusing on interventions that influence mitochondrial health, cognitive performance, immune function, metabolic regulation, and maintenance of muscle mass in older adults.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicTocotrienols Cognitive Performance Meta-Analysis
claimRecent findings Evidence indicates that several targeted nutrients, including protein, probiotics, antioxidants, and emerging mitochondrial-support compounds, may contribute to healthy aging.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicTocotrienols Cognitive Performance Meta-Analysis
claimA personalized, evidence-informed supplementation strategy integrated with exercise and balanced nutrition may help optimize physiological function in aging adults.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.
topicTocotrienols Cognitive Performance Meta-Analysis
claimPurpose of review Aging is marked by progressive physiological decline driven by chronic inflammation, mitochondrial dysfunction, and impaired metabolic and musculoskeletal resilience.
evidence level4
citationKurtz JA (2026)
sourceTargeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits.