evidence table

Tocotrienol Cholesterol Meta-Analysis Evidence Table

Name: Tocotrienol Cholesterol Meta-Analysis Evidence Table
Creator: Migaku
License: https://creativecommons.org/licenses/by/4.0/

Structured evidence table for Tocotrienol Cholesterol Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topic	claim	evidence level	citation	source
Tocotrienol Cholesterol Meta-Analysis	Nutritional demands increase during this period, but populations with limited access to vitamin E–rich foods, such as oils, nuts, and seeds, are at risk of deficiency (Rebouças et al. ; Busso et al. ).	1	Carneiro Byanca Rodrigues (2026)	Efficacy of Vitamin E Supplementation During Pregnancy on the Vitamin E Nutritional Status of the Mother–Child Dyad: A Systematic Review and Meta‐Analysis of Randomized Controlled Trial
Tocotrienol Cholesterol Meta-Analysis	2015 2005 2005 2014 2021 2015 Recent studies suggest that low vitamin E levels, defined as serum concentrations below 12 μmol/L (Péter et al. ), increase maternal oxidative stress, thereby raising the risk of complications such as preeclampsia and placental abruption (Debier and Larondelle ).	1	Carneiro Byanca Rodrigues (2026)	Efficacy of Vitamin E Supplementation During Pregnancy on the Vitamin E Nutritional Status of the Mother–Child Dyad: A Systematic Review and Meta‐Analysis of Randomized Controlled Trial
Tocotrienol Cholesterol Meta-Analysis	found that vitamin E combined with other supplements did not prevent fetal or neonatal death, preterm birth, preeclampsia, or IUGR, but the lack of data on isolated α‐TOH prevents conclusions about its independent effect (Rumbold et al. ).	1	Carneiro Byanca Rodrigues (2026)	Efficacy of Vitamin E Supplementation During Pregnancy on the Vitamin E Nutritional Status of the Mother–Child Dyad: A Systematic Review and Meta‐Analysis of Randomized Controlled Trial
Tocotrienol Cholesterol Meta-Analysis	2017 2018 2021 Vitamin E is a group of fat‐soluble compounds that includes tocopherols and tocotrienols, each subdivided into four distinct forms (α‐, β‐, γ‐, and δ‐).	1	Carneiro Byanca Rodrigues (2026)	Efficacy of Vitamin E Supplementation During Pregnancy on the Vitamin E Nutritional Status of the Mother–Child Dyad: A Systematic Review and Meta‐Analysis of Randomized Controlled Trial
Tocotrienol Cholesterol Meta-Analysis	Hyperlipidemia, characterized by elevated lipid levels, is a major risk factor for cardiovascular diseases (CVD), including atherosclerosis.	1	Abdah HW (2025)	Effect of tocotrienol-rich fraction (TRF) on lipid profile in hyperlipidemic experimental animal model: a systematic review and meta-analysis.
Tocotrienol Cholesterol Meta-Analysis	TRF significantly reduced total cholesterol (effect size = - 4.675, p < 0.0001), LDL (- 4.847, p < 0.0001), and triglycerides (- 4.736, p < 0.0001), while significantly increasing HDL (4.001, p < 0.0001), particularly in rats and mice.	1	Abdah HW (2025)	Effect of tocotrienol-rich fraction (TRF) on lipid profile in hyperlipidemic experimental animal model: a systematic review and meta-analysis.
Tocotrienol Cholesterol Meta-Analysis	Tocotrienol-rich fraction (TRF), a potent form of vitamin E, has demonstrated promising lipid-lowering effects due to its antioxidant and anti-inflammatory properties.	1	Abdah HW (2025)	Effect of tocotrienol-rich fraction (TRF) on lipid profile in hyperlipidemic experimental animal model: a systematic review and meta-analysis.