Structured evidence table for Theobromine Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Theobromine Cognition Randomized Trial | Neurodegenerative conditions such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and other associated ailments rank among the foremost contributors to disability-adjusted life years on a global scale (). | 3 | Li LePing (2026) | Cocoa polyphenols in brain health: BDNF/CREB-mediated mechanisms in depression, cognition, and the gut–brain axis |
| Theobromine Cognition Randomized Trial | Dysbiosis of the gut microbiota has been associated with both depressive disorders and neurodegenerative pathologies, affecting neuroinflammation, neurotransmitter synthesis, and the integrity of the blood–brain barrier (BBB) (). | 3 | Li LePing (2026) | Cocoa polyphenols in brain health: BDNF/CREB-mediated mechanisms in depression, cognition, and the gut–brain axis |
| Theobromine Cognition Randomized Trial | Empirical evidence indicates that these bioactive constituents possess the ability to traverse the BBB and accumulate within cerebral regions associated with cognitive functions, particularly in the hippocampus (,). | 3 | Li LePing (2026) | Cocoa polyphenols in brain health: BDNF/CREB-mediated mechanisms in depression, cognition, and the gut–brain axis |
| Theobromine Cognition Randomized Trial | 1 2 3 4 5 6 7 8 9 10 11 Neurological disorders and depressive disorders represent a significant and intensifying global health challenge, influenced in part by the rise in life expectancy and demographic aging. | 3 | Li LePing (2026) | Cocoa polyphenols in brain health: BDNF/CREB-mediated mechanisms in depression, cognition, and the gut–brain axis |
| Theobromine Cognition Randomized Trial | Thus, this review aimed to provide an overview of the latest research results on the effects of cacao on the prevention of CVDs and on biomarkers associated with these mechanisms. | 3 | Lee YG (2026) | Cardiovascular Protective Effects and Mechanisms of Action of Cacao: A Comprehensive Review. |
| Theobromine Cognition Randomized Trial | Cacao, the primary raw material for chocolate and certain beverages, is widely cultivated in the Americas and Asia. | 3 | Lee YG (2026) | Cardiovascular Protective Effects and Mechanisms of Action of Cacao: A Comprehensive Review. |
| Theobromine Cognition Randomized Trial | Furthermore, various components of cacao, including phenolic compounds, have been shown to be effective in preventing numerous diseases. | 3 | Lee YG (2026) | Cardiovascular Protective Effects and Mechanisms of Action of Cacao: A Comprehensive Review. |
Source documents