Structured evidence table for Taurine Sleep Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Taurine Sleep Randomized Trial | Cirrhosis is a major and growing global cause of morbidity and premature mortality, driven largely by alcohol-associated liver disease and metabolic dysfunction–associated steatotic liver disease alongside chronic viral hepatitis. | 2 | Sasidharan Swarup (2026) | A randomized controlled trial of L -taurine for fatigue in decompensated cirrhosis |
| Taurine Sleep Randomized Trial | Fatigue in chronic liver disease is a multidimensional syndrome involving reduced physical and mental energy, impaired motivation, reduced endurance, and slowed cognition that is often poorly relieved by rest. | 2 | Sasidharan Swarup (2026) | A randomized controlled trial of L -taurine for fatigue in decompensated cirrhosis |
| Taurine Sleep Randomized Trial | , , Despite its impact, there is no universally effective, guideline-endorsed pharmacologic therapy for fatigue in cirrhosis. | 2 | Sasidharan Swarup (2026) | A randomized controlled trial of L -taurine for fatigue in decompensated cirrhosis |
| Taurine Sleep Randomized Trial | As the cirrhosis population ages and lives longer with decompensation, the clinical focus can no longer remain limited to “hard” outcomes (bleeding, ascites, and encephalopathy) alone; patient-reported outcomes and day-to-day functioning matter because they determine disability, health care use, and whether patients can participate meaningfully in care pathways. | 2 | Sasidharan Swarup (2026) | A randomized controlled trial of L -taurine for fatigue in decompensated cirrhosis |
| Taurine Sleep Randomized Trial | Methods Building on these findings, we identified candidate nutrients found in foods that could enhance brain GSH production as a possible approach to sustain motivated behaviors. | 2 | Anlacan VM (2026) | A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial. |
| Taurine Sleep Randomized Trial | The blend was also found to reduce the number of lapses during the Psychomotor Vigilance Task after 14 days, but not after 28 days of intake. | 2 | Anlacan VM (2026) | A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial. |
| Taurine Sleep Randomized Trial | Introduction Motivation is a key driver in achieving goals and performing daily tasks, involving cost-benefit valuations of the amount of effort required for a particular reward and can be influenced by socio-environmental factors and neurological conditions that may impact the brain reward circuitry. | 2 | Anlacan VM (2026) | A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial. |
| Taurine Sleep Randomized Trial | Notably, research has shown that higher glutathione levels (GSH) in the nucleus accumbens are linked with better and more consistent performance in effortful tasks in both preclinical models and humans. | 2 | Anlacan VM (2026) | A nutritional blend of taurine, vitamins B6, B9, and B12 improves motivated behaviors in healthy adults-a double-blinded randomized clinical trial. |
Source documents