topicSulforaphane Cardiometabolic Randomized Trial
claimBackground/Objectives: Obesity is a major global health challenge characterized by adipose tissue dysfunction, insulin resistance, chronic low-grade inflammation, oxidative stress, mitochondrial dysfunction, and increased cardiometabolic risk.
evidence level4
citationPoulios E (2026)
sourceSulforaphane and Broccoli-Derived Preparations in Obesity and Obesity-Related Metabolic Dysfunction: Mechanistic Insights, Preclinical Evidence, and Clinical Perspectives.
topicSulforaphane Cardiometabolic Randomized Trial
claimThis narrative review critically evaluates the current evidence regarding the role of sulforaphane and broccoli-derived preparations in obesity and obesity-associated metabolic dysfunction.
evidence level4
citationPoulios E (2026)
sourceSulforaphane and Broccoli-Derived Preparations in Obesity and Obesity-Related Metabolic Dysfunction: Mechanistic Insights, Preclinical Evidence, and Clinical Perspectives.
topicSulforaphane Cardiometabolic Randomized Trial
claimAnimal studies further report reductions in adiposity, insulin resistance, hepatic steatosis, oxidative stress, and chronic inflammation, together with improvements in energy expenditure, metabolic flexibility, and obesity-associated metabolic abnormalities.
evidence level4
citationPoulios E (2026)
sourceSulforaphane and Broccoli-Derived Preparations in Obesity and Obesity-Related Metabolic Dysfunction: Mechanistic Insights, Preclinical Evidence, and Clinical Perspectives.
topicSulforaphane Cardiometabolic Randomized Trial
claimDespite substantial therapeutic advances, limitations related to cost, adverse effects, and long-term adherence have stimulated interest in complementary nutritional approaches.
evidence level4
citationPoulios E (2026)
sourceSulforaphane and Broccoli-Derived Preparations in Obesity and Obesity-Related Metabolic Dysfunction: Mechanistic Insights, Preclinical Evidence, and Clinical Perspectives.
topicSulforaphane Cardiometabolic Randomized Trial
claimBrSp-fed females had a lower body weight and visceral adiposity while BrSp-fed males exhibited improved glucose tolerance and reduced blood pressure when compared to their control counterparts.
evidence level4
citationNoble RMN (2022)
sourceBroccoli Sprouts Promote Sex-Dependent Cardiometabolic Health and Longevity in Long-Evans Rats.
topicSulforaphane Cardiometabolic Randomized Trial
claimThese findings highlight the sex-dependent benefits of BrSp on improving longevity and delaying cardiometabolic decline associated with aging in rats.
evidence level4
citationNoble RMN (2022)
sourceBroccoli Sprouts Promote Sex-Dependent Cardiometabolic Health and Longevity in Long-Evans Rats.
topicSulforaphane Cardiometabolic Randomized Trial
claimAntioxidants and anti-inflammatory compounds are potential candidates to prevent age-related chronic diseases.
evidence level4
citationNoble RMN (2022)
sourceBroccoli Sprouts Promote Sex-Dependent Cardiometabolic Health and Longevity in Long-Evans Rats.
topicSulforaphane Cardiometabolic Randomized Trial
claimBroccoli sprouts (BrSp) are a rich source of sulforaphane-a bioactive metabolite known for its antioxidant and anti-inflammatory properties.
evidence level4
citationNoble RMN (2022)
sourceBroccoli Sprouts Promote Sex-Dependent Cardiometabolic Health and Longevity in Long-Evans Rats.