topicSodium Bicarbonate High-Intensity Exercise Meta-Analysis
claimHowever, comparisons among active conditions provided no clear evidence that co-ingestion was superior to either supplement alone.
evidence level1
citationLiu S (2026)
sourceIndividual and Combined Effects of Acute Caffeine and Sodium Bicarbonate Supplementation on Exercise Performance and Metabolic Responses: A Bayesian Network Meta-Analysis of Co-Supplementation Trials.
topicSodium Bicarbonate High-Intensity Exercise Meta-Analysis
claimSB increased blood pH (g = 0.95) and blood lactate (g = 1.13), whereas caffeine reduced blood bicarbonate (g = -0.89).
evidence level1
citationLiu S (2026)
sourceIndividual and Combined Effects of Acute Caffeine and Sodium Bicarbonate Supplementation on Exercise Performance and Metabolic Responses: A Bayesian Network Meta-Analysis of Co-Supplementation Trials.
topicSodium Bicarbonate High-Intensity Exercise Meta-Analysis
claimBackground : Caffeine and sodium bicarbonate (SB) are widely used ergogenic supplements that influence exercise performance through distinct physiological mechanisms and may differentially modulate exercise-related metabolic responses.
evidence level1
citationLiu S (2026)
sourceIndividual and Combined Effects of Acute Caffeine and Sodium Bicarbonate Supplementation on Exercise Performance and Metabolic Responses: A Bayesian Network Meta-Analysis of Co-Supplementation Trials.
topicSodium Bicarbonate High-Intensity Exercise Meta-Analysis
claimWhether their co-ingestion provides benefits beyond either supplement alone remains uncertain.
evidence level1
citationLiu S (2026)
sourceIndividual and Combined Effects of Acute Caffeine and Sodium Bicarbonate Supplementation on Exercise Performance and Metabolic Responses: A Bayesian Network Meta-Analysis of Co-Supplementation Trials.
topicSodium Bicarbonate High-Intensity Exercise Meta-Analysis
claim−1 − + −1 −1 −1 1 1 2 4 2 Sodium bicarbonate (SB), commonly known as baking soda, is an extracellular buffering agent with increasing research evidence supporting its use as an ergogenic aid.
evidence level3
citationAntonio Brandi (2026)
sourceCommon questions and misconceptions of sodium bicarbonate as an ergogenic aid: what does the science really show?
topicSodium Bicarbonate High-Intensity Exercise Meta-Analysis
claimThese results showed that the acidosis response associated with the exercise task significantly reduced the blood's buffering capacity and its ability to buffer the increase in hydrogen ions (H) associated with lactate accumulation, resultantly limiting the runner's endurance capacity.
evidence level3
citationAntonio Brandi (2026)
sourceCommon questions and misconceptions of sodium bicarbonate as an ergogenic aid: what does the science really show?
topicSodium Bicarbonate High-Intensity Exercise Meta-Analysis
claim3 4 5–7 There is robust evidence supporting the ergogenic effects of SB on exercise performance []; however, the potential gastrointestinal symptoms (GIS) associated with the compound likely reduces its usage amongst athletes [].
evidence level3
citationAntonio Brandi (2026)
sourceCommon questions and misconceptions of sodium bicarbonate as an ergogenic aid: what does the science really show?
topicSodium Bicarbonate High-Intensity Exercise Meta-Analysis
claimIt is commonly ingested in doses from 0.2 to 0.5 g·kgbody mass (BM) and intended to improve performance that utilizes non-oxidative metabolism.
evidence level3
citationAntonio Brandi (2026)
sourceCommon questions and misconceptions of sodium bicarbonate as an ergogenic aid: what does the science really show?