Structured evidence table for Sesamin Lipid Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Sesamin Lipid Meta-Analysis | Sesamum indicum 1 2 3 4 5 6 7 8 Sesamin, a principal lignan found in sesame seeds (L.), has attracted considerable attention due to its diverse biological activities and potential health benefits [,,,,,]. | 4 | Zhu Xiliang (2026) | Sesamin Ameliorates High‐Sugar, High‐Fat Diet‐Induced Hepatic Dysfunction via CYP1A2 ‐Mediated Regulation of Lipid Metabolism and Oxidative Stress |
| Sesamin Lipid Meta-Analysis | While primarily present in sesame seeds, sesamin is also found in smaller quantities in other plant sources such as pumpkin seeds and flaxseeds. | 4 | Zhu Xiliang (2026) | Sesamin Ameliorates High‐Sugar, High‐Fat Diet‐Induced Hepatic Dysfunction via CYP1A2 ‐Mediated Regulation of Lipid Metabolism and Oxidative Stress |
| Sesamin Lipid Meta-Analysis | 17 18 19 Despite the growing evidence supporting sesamin's beneficial effects on metabolic health, the precise mechanisms underlying its action remain largely unclear. | 4 | Zhu Xiliang (2026) | Sesamin Ameliorates High‐Sugar, High‐Fat Diet‐Induced Hepatic Dysfunction via CYP1A2 ‐Mediated Regulation of Lipid Metabolism and Oxidative Stress |
| Sesamin Lipid Meta-Analysis | This natural compound, first isolated in the 1950s, is characterized by its unique structure comprising two methylenedioxyphenyl groups linked by a furofuran skeleton [,]. | 4 | Zhu Xiliang (2026) | Sesamin Ameliorates High‐Sugar, High‐Fat Diet‐Induced Hepatic Dysfunction via CYP1A2 ‐Mediated Regulation of Lipid Metabolism and Oxidative Stress |
| Sesamin Lipid Meta-Analysis | Methods Network pharmacology was applied to predict potential targets and pathways associated with the anti-atherosclerotic activity of Yishen Huoxue Huatan. | 4 | Chen X (2026) | Sesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury <i>via</i> m<sup>6</sup>A-dependent regulation of SREBF1 expression. |
| Sesamin Lipid Meta-Analysis | Results Network pharmacology identified sesamin as a major bioactive constituent associated with atherosclerosis-related and epigenetic regulatory pathways. | 4 | Chen X (2026) | Sesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury <i>via</i> m<sup>6</sup>A-dependent regulation of SREBF1 expression. |
| Sesamin Lipid Meta-Analysis | In ApoE -/- mice, sesamin reduced aortic lipid deposition, alleviated vascular injury, and improved dyslipidemia. | 4 | Chen X (2026) | Sesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury <i>via</i> m<sup>6</sup>A-dependent regulation of SREBF1 expression. |
| Sesamin Lipid Meta-Analysis | Objective This study was designed to elucidate the molecular pathways responsible for anti-atherosclerotic effects of the traditional Chinese medicine formula Yishen Huoxue Huatan, with a focus on its key active component sesamin. | 4 | Chen X (2026) | Sesamin attenuates atherosclerosis by alleviating vascular endothelial ferroptosis-related injury <i>via</i> m<sup>6</sup>A-dependent regulation of SREBF1 expression. |
Source documents