topicSelenium Thyroid Function Meta-Analysis
claimCombination therapy significantly reduced TSH levels compared with Sel monotherapy (SMD -1.26; 95% CI -1.51 to -1.00; p 2 = 0%), and TSA suggested that this finding may be robust, although the evidence is limited by the small number of studies.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Function Meta-Analysis
claimTgAb levels were also significantly reduced (SMD -0.51; 95% CI -0.78 to -0.24; p 2 = 0%); however, TSA indicated a potential risk of type I error.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Function Meta-Analysis
claimConclusions : MI combined with Sel was associated with a significant reduction in TSH levels compared with Sel alone in patients with HT and subclinical hypothyroidism, suggesting a potential therapeutic benefit.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Function Meta-Analysis
claimIntroduction : Hashimoto's thyroiditis (HT) is the leading cause of hypothyroidism in iodine-sufficient regions and often presents with subclinical hypothyroidism.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Function Meta-Analysis
claimAlthough biochemical euthyroidism can usually be achieved with appropriate hormone therapy, a subset of patients continues to report persistent symptoms such as fatigue, cognitive difficulty, weight changes, and reduced quality of life (QOL), even after biochemical optimization.
evidence level4
citationPersonius L (2026)
sourceBeyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto's thyroiditis.
topicSelenium Thyroid Function Meta-Analysis
claimThis narrative review summarizes current evidence on adjunctive, non-hormonal, and non-surgical management strategies for HT.
evidence level4
citationPersonius L (2026)
sourceBeyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto's thyroiditis.
topicSelenium Thyroid Function Meta-Analysis
claimSome studies have reported improvements in QOL, autoimmune activity, or symptom burden; however, the existing evidence is heterogeneous, methodologically limited, and often based on small or uncontrolled studies.
evidence level4
citationPersonius L (2026)
sourceBeyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto's thyroiditis.
topicSelenium Thyroid Function Meta-Analysis
claimBackground and objective Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disorder and the leading cause of hypothyroidism worldwide.
evidence level4
citationPersonius L (2026)
sourceBeyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto's thyroiditis.