topicSelenium Thyroid Autoimmunity Meta-Analysis
claimCombination therapy significantly reduced TSH levels compared with Sel monotherapy (SMD -1.26; 95% CI -1.51 to -1.00; p 2 = 0%), and TSA suggested that this finding may be robust, although the evidence is limited by the small number of studies.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Autoimmunity Meta-Analysis
claimTgAb levels were also significantly reduced (SMD -0.51; 95% CI -0.78 to -0.24; p 2 = 0%); however, TSA indicated a potential risk of type I error.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Autoimmunity Meta-Analysis
claimConclusions : MI combined with Sel was associated with a significant reduction in TSH levels compared with Sel alone in patients with HT and subclinical hypothyroidism, suggesting a potential therapeutic benefit.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Autoimmunity Meta-Analysis
claimIntroduction : Hashimoto's thyroiditis (HT) is the leading cause of hypothyroidism in iodine-sufficient regions and often presents with subclinical hypothyroidism.
evidence level1
citationStanchev P (2026)
sourceMyo-Inositol Plus Selenium vs. Selenium Alone in Hashimoto's Thyroiditis with Subclinical Hypothyroidism: A Systematic Review and Updated Meta-Analysis with Trial Sequential Analysis.
topicSelenium Thyroid Autoimmunity Meta-Analysis
claimIt is associated with elevated anti-thyroid peroxidase antibodies (TPOAb) and often anti-thyroglobulin antibodies (TgAb) ().
evidence level4
citationPersonius Lydia (2026)
sourceBeyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto’s thyroiditis
topicSelenium Thyroid Autoimmunity Meta-Analysis
claimThe incidence of HT has increased over recent decades and is higher with advancing age, in women, and in iodine-sufficient populations (,).
evidence level4
citationPersonius Lydia (2026)
sourceBeyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto’s thyroiditis
topicSelenium Thyroid Autoimmunity Meta-Analysis
claimWet cupping was associated with a statistically significant reduction in anti-thyroid autoantibody levels and a decrease in TSH despite stable thyroid hormone dosing ().
evidence level4
citationPersonius Lydia (2026)
sourceBeyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto’s thyroiditis
topicSelenium Thyroid Autoimmunity Meta-Analysis
claim1 2 3 4 Hashimoto’s thyroiditis (HT) is an autoimmune disorder that has been well documented as the leading cause of hypothyroidism and the most common form of thyroiditis ().
evidence level4
citationPersonius Lydia (2026)
sourceBeyond levothyroxine: a narrative review of adjunctive management strategies for Hashimoto’s thyroiditis