Structured evidence table for Selenium Cognition Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Selenium Cognition Meta-Analysis | In the late-onset groups, the apolipoprotein E (APOE) gene, the strongest and most consistently replicated genetic risk factor, is associated with AD. | 3 | Lawal Rasheedat (2026) | Interactions Between Blood Nutritional Biomarkers and Apolipoprotein E ε4 in the Progression of Mild Cognitive Impairment in Alzheimer’s Disease |
| Selenium Cognition Meta-Analysis | The ε4 allele increases the likelihood of developing AD and is associated with greater neuroinflammation and impaired lipid transport []. | 3 | Lawal Rasheedat (2026) | Interactions Between Blood Nutritional Biomarkers and Apolipoprotein E ε4 in the Progression of Mild Cognitive Impairment in Alzheimer’s Disease |
| Selenium Cognition Meta-Analysis | 2 16 17 18 14 19 18 Although individuals with MCI face an elevated risk of progression to Alzheimer’s disease [,,], if not controlled properly [], the trajectories are highly variable. | 3 | Lawal Rasheedat (2026) | Interactions Between Blood Nutritional Biomarkers and Apolipoprotein E ε4 in the Progression of Mild Cognitive Impairment in Alzheimer’s Disease |
| Selenium Cognition Meta-Analysis | 1 2 3 4 Alzheimer’s disease (AD) is the most common cause of dementia [], which accounts for 55.2 million dementia cases estimated globally and is projected to exceed 75.6 million cases by 2030 []. | 3 | Lawal Rasheedat (2026) | Interactions Between Blood Nutritional Biomarkers and Apolipoprotein E ε4 in the Progression of Mild Cognitive Impairment in Alzheimer’s Disease |
| Selenium Cognition Meta-Analysis | Importantly, these biological changes manifest most meaningfully through declines in functional capacity, including reduced muscle strength, impaired metabolic regulation, diminished cognitive performance, and increased disease risk. | 4 | Kurtz Jennifer A. (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits |
| Selenium Cognition Meta-Analysis | This article aims to synthesize evidence from human studies evaluating dietary supplements that directly or indirectly modulate the recognized hallmarks of aging, such as mitochondrial dysfunction, oxidative stress, inflammation, and proteostasis. | 4 | Kurtz Jennifer A. (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits |
| Selenium Cognition Meta-Analysis | Rather than providing an exhaustive account of all supplements ever studied, this review focuses on representative compounds with the strongest or most emerging human evidence. | 4 | Kurtz Jennifer A. (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits |
| Selenium Cognition Meta-Analysis | Aging is a complex, multifaceted process marked by a gradual decline in physiological. | 4 | Kurtz Jennifer A. (2026) | Targeted Supplementation and Nutritional Strategies for Healthy Aging: A Review of Physiological and Molecular Benefits |
Source documents