topicSelenium Blood Pressure Meta-Analysis
claimThe analysis calculated summary relative risks (RR) and 95% confidence intervals (95% CI) for the risk of hypertension by comparing the highest versus lowest levels of circulating selenium and using random-effects models.
evidence level1
citationKhodadadi H (2025)
sourceDose-response association between circulating selenium and blood pressure: a systematic review and meta-analysis.
topicSelenium Blood Pressure Meta-Analysis
claimThe highest versus lowest level of circulating selenium was not significantly related to risk of hypertension (RR:1.15; 95% CI: 0.99-1.33).
evidence level1
citationKhodadadi H (2025)
sourceDose-response association between circulating selenium and blood pressure: a systematic review and meta-analysis.
topicSelenium Blood Pressure Meta-Analysis
claimlowest circulating selenium was associated with a 36% higher risk of hypertension in women (95% CI: 1.03-1.81).
evidence level1
citationKhodadadi H (2025)
sourceDose-response association between circulating selenium and blood pressure: a systematic review and meta-analysis.
topicSelenium Blood Pressure Meta-Analysis
claimAim and scope Hypertension is considered a global health issue due to its growing prevalence.
evidence level1
citationKhodadadi H (2025)
sourceDose-response association between circulating selenium and blood pressure: a systematic review and meta-analysis.
topicSelenium Blood Pressure Meta-Analysis
claimDespite major advancements in pharmacotherapies and interventional cardiology, substantial residual risk persists among patients with established disease ().
evidence level3
citationWu Xun (2026)
sourceAdvances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives
topicSelenium Blood Pressure Meta-Analysis
claimAdditionally, many nutraceuticals are perceived to possess favorable safety and tolerability profiles compared to conventional medications, making them attractive for long-term risk reduction ().
evidence level3
citationWu Xun (2026)
sourceAdvances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives
topicSelenium Blood Pressure Meta-Analysis
claimBanach et al., 2018 Cicero et al., 2017 Sesso et al., 2008 However, the field is marked by heterogeneous and sometimes contradictory evidence.
evidence level3
citationWu Xun (2026)
sourceAdvances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives
topicSelenium Blood Pressure Meta-Analysis
claimRoth et al., 2020 Ganda et al., 2018 Visseren et al., 2021 Cardiovascular disease (CVD) is the leading cause of mortality worldwide, accounting for nearly one-third of global deaths each year ().
evidence level3
citationWu Xun (2026)
sourceAdvances in cardiovascular supplementation: mechanisms, efficacy, and clinical perspectives