topicSage Sleep Randomized Trial
claimGiven the exploratory nature of this study, we used a significance threshold of p P 0.001), whereas 8-hydroxy-2'-deoxyguanosine levels decreased over time.ConclusionsAmong active duty service members with chronic pain, changes in physical function and sleep-related function were associated with changes in oxidative stress.
evidence level2
citationSnow TJ (2026)
sourceAssociation of physical function and sleep with oxidative stress in adults with chronic pain: A pragmatic clinical trial secondary analysis.
topicSage Sleep Randomized Trial
claimObjectiveThis study aimed to evaluate the potential utility of 8-hydroxy-2'-deoxyguanosine as a biomarker for pain-related functional outcomes.MethodsThis is a secondary analysis of a pragmatic clinical trial that recruited active duty service members with chronic pain.
evidence level2
citationSnow TJ (2026)
sourceAssociation of physical function and sleep with oxidative stress in adults with chronic pain: A pragmatic clinical trial secondary analysis.
topicSage Sleep Randomized Trial
claimParticipants underwent a 6-week interdisciplinary pain management program and completed measures of sleep-related function and physical function, including objective measures of treadmill, lift, and carry battery.
evidence level2
citationSnow TJ (2026)
sourceAssociation of physical function and sleep with oxidative stress in adults with chronic pain: A pragmatic clinical trial secondary analysis.
topicSage Sleep Randomized Trial
claimBackground Insomnia during pregnancy is a modifiable risk factor for depression.
evidence level2
citationFelder JN (2026)
sourceDigital Cognitive Behavioral Therapy for Insomnia Versus Sleep Hygiene Education for Prevention of Perinatal Depression: Protocol for a Randomized Clinical Trial.
topicSage Sleep Randomized Trial
claimResearch in nonpregnant populations and preliminary findings in a pregnant population suggest that targeting insomnia with digital cognitive behavioral therapy for insomnia (CBT-I) may prevent depression.
evidence level2
citationFelder JN (2026)
sourceDigital Cognitive Behavioral Therapy for Insomnia Versus Sleep Hygiene Education for Prevention of Perinatal Depression: Protocol for a Randomized Clinical Trial.