Saffron Stress Meta-Analysis Evidence Table

Structured evidence table for Saffron Stress Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Saffron Stress Meta-AnalysisBackground and aim Interest of herbal supplements as alternatives to conventional treatments for erectile dysfunction (ED) has increased markedly.1Ho CY (2025)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials.
Saffron Stress Meta-AnalysisResults and conclusion Fourteen RCTs with a total of 1227 males with ED were included.1Ho CY (2025)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials.
Saffron Stress Meta-AnalysisIn contrast, evidence for other agents such as Tribulus terrestris and Maca remains insufficient, underscoring the need for larger, high-quality trials with longer follow-up.1Ho CY (2025)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials.
Saffron Stress Meta-AnalysisThis systematic review and meta-analysis aimed to evaluate the effectiveness of herbal supplements in treating ED.1Ho CY (2025)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials.
Saffron Stress Meta-AnalysisThis literature review synthesises evidence from randomised controlled trials, meta-analyses, safety data, dosing patterns, proposed mechanisms, and guideline positioning regarding saffron in depression, with a focus on adult major depressive disorder and related depressive symptomatology.4Dimech L (2026)The Role of Saffron in the Treatment of Depression: A Literature Review.
Saffron Stress Meta-AnalysisAcross placebo-controlled trials in mild-to-moderate depression, saffron, most commonly administered at 30 mg per day for approximately six weeks, has been associated with clinically meaningful reductions in depressive symptom severity, typically measured using the Hamilton Depression Rating Scale (HAM-D).4Dimech L (2026)The Role of Saffron in the Treatment of Depression: A Literature Review.
Saffron Stress Meta-AnalysisMeta-analytic evidence generally indicates superiority over placebo and similar efficacy to selective serotonin reuptake inhibitors (SSRIs), with an overall favourable short-term tolerability profile; however, confidence is constrained by small sample sizes, restricted settings, variable product standardisation (including stigma versus petal preparations), and risk of bias/publication bias.4Dimech L (2026)The Role of Saffron in the Treatment of Depression: A Literature Review.
Saffron Stress Meta-AnalysisSaffron ( Crocus sativus L.) has attracted increasing interest as a nutraceutical option for depressive disorders, particularly for patients who experience incomplete response or poor tolerability with conventional treatments.4Dimech L (2026)The Role of Saffron in the Treatment of Depression: A Literature Review.
topicSaffron Stress Meta-Analysis
claimBackground and aim Interest of herbal supplements as alternatives to conventional treatments for erectile dysfunction (ED) has increased markedly.
evidence level1
citationHo CY (2025)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials.
topicSaffron Stress Meta-Analysis
claimResults and conclusion Fourteen RCTs with a total of 1227 males with ED were included.
evidence level1
citationHo CY (2025)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials.
topicSaffron Stress Meta-Analysis
claimIn contrast, evidence for other agents such as Tribulus terrestris and Maca remains insufficient, underscoring the need for larger, high-quality trials with longer follow-up.
evidence level1
citationHo CY (2025)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials.
topicSaffron Stress Meta-Analysis
claimThis systematic review and meta-analysis aimed to evaluate the effectiveness of herbal supplements in treating ED.
evidence level1
citationHo CY (2025)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials.
topicSaffron Stress Meta-Analysis
claimThis literature review synthesises evidence from randomised controlled trials, meta-analyses, safety data, dosing patterns, proposed mechanisms, and guideline positioning regarding saffron in depression, with a focus on adult major depressive disorder and related depressive symptomatology.
evidence level4
citationDimech L (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review.
topicSaffron Stress Meta-Analysis
claimAcross placebo-controlled trials in mild-to-moderate depression, saffron, most commonly administered at 30 mg per day for approximately six weeks, has been associated with clinically meaningful reductions in depressive symptom severity, typically measured using the Hamilton Depression Rating Scale (HAM-D).
evidence level4
citationDimech L (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review.
topicSaffron Stress Meta-Analysis
claimMeta-analytic evidence generally indicates superiority over placebo and similar efficacy to selective serotonin reuptake inhibitors (SSRIs), with an overall favourable short-term tolerability profile; however, confidence is constrained by small sample sizes, restricted settings, variable product standardisation (including stigma versus petal preparations), and risk of bias/publication bias.
evidence level4
citationDimech L (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review.
topicSaffron Stress Meta-Analysis
claimSaffron ( Crocus sativus L.) has attracted increasing interest as a nutraceutical option for depressive disorders, particularly for patients who experience incomplete response or poor tolerability with conventional treatments.
evidence level4
citationDimech L (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review.

Source documents

  1. Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials.
  2. The Role of Saffron in the Treatment of Depression: A Literature Review.