stress mood

Saffron Skin Health Randomized Trial Evidence Table

Structured evidence table for Saffron Skin Health Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Saffron Skin Health Randomized TrialSaffron was also associated with greater improvements in self-esteem (adjusted mean difference: 1.43; 95% CI: 0.22, 2.64; d = 0.51; p = 0.022) and sleep-related impairment (adjusted mean difference: 2.99; 95% CI: 0.12, 5.86; d = 0.45; p = 0.041).2Lopresti AL (2026)The effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
Saffron Skin Health Randomized TrialConclusion Supplementation with a saffron extract (Affron®) for 12 weeks was associated with improvements in depressive symptoms.2Lopresti AL (2026)The effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
Saffron Skin Health Randomized TrialBackground Depression is commonly accompanied by sleep disturbances and low self-esteem.2Lopresti AL (2026)The effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
Saffron Skin Health Randomized TrialSaffron ( Crocus sativus L.) has demonstrated antidepressant and sleep-enhancing effects in previous clinical trials; however, its efficacy in women experiencing both low mood and poor sleep has not been specifically examined.2Lopresti AL (2026)The effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
Saffron Skin Health Randomized TrialWith the increased demand for saffron, farmers in various countries worldwide have begun cultivating.3Tufail Tabussam (2025)Functional, Nutraceutical and Health Endorsing Perspectives of Saffron
Saffron Skin Health Randomized TrialSaffron's health‐promoting properties can also be found in ancient Chinese, Unani, Ayurvedic, and Homeopathic prescriptions (Abu‐Izneid et al. ).3Tufail Tabussam (2025)Functional, Nutraceutical and Health Endorsing Perspectives of Saffron
Saffron Skin Health Randomized TrialActive substances such as safranal, picrocrocin, crocetin, and crocin can be found in variable amounts in the tepals, stigmas, leaves, and corns of theplant.3Tufail Tabussam (2025)Functional, Nutraceutical and Health Endorsing Perspectives of Saffron
Saffron Skin Health Randomized TrialCrocus sativus C. sativus C. sativus C. sativus 2019 2006 Saffron, also known asL., is a popular herbal remedy widely grown in India, Iran, and the Mediterranean.3Tufail Tabussam (2025)Functional, Nutraceutical and Health Endorsing Perspectives of Saffron
topicSaffron Skin Health Randomized Trial
claimSaffron was also associated with greater improvements in self-esteem (adjusted mean difference: 1.43; 95% CI: 0.22, 2.64; d = 0.51; p = 0.022) and sleep-related impairment (adjusted mean difference: 2.99; 95% CI: 0.12, 5.86; d = 0.45; p = 0.041).
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Skin Health Randomized Trial
claimConclusion Supplementation with a saffron extract (Affron®) for 12 weeks was associated with improvements in depressive symptoms.
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Skin Health Randomized Trial
claimBackground Depression is commonly accompanied by sleep disturbances and low self-esteem.
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Skin Health Randomized Trial
claimSaffron ( Crocus sativus L.) has demonstrated antidepressant and sleep-enhancing effects in previous clinical trials; however, its efficacy in women experiencing both low mood and poor sleep has not been specifically examined.
evidence level2
citationLopresti AL (2026)
sourceThe effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
topicSaffron Skin Health Randomized Trial
claimWith the increased demand for saffron, farmers in various countries worldwide have begun cultivating.
evidence level3
citationTufail Tabussam (2025)
sourceFunctional, Nutraceutical and Health Endorsing Perspectives of Saffron
topicSaffron Skin Health Randomized Trial
claimSaffron's health‐promoting properties can also be found in ancient Chinese, Unani, Ayurvedic, and Homeopathic prescriptions (Abu‐Izneid et al. ).
evidence level3
citationTufail Tabussam (2025)
sourceFunctional, Nutraceutical and Health Endorsing Perspectives of Saffron
topicSaffron Skin Health Randomized Trial
claimActive substances such as safranal, picrocrocin, crocetin, and crocin can be found in variable amounts in the tepals, stigmas, leaves, and corns of theplant.
evidence level3
citationTufail Tabussam (2025)
sourceFunctional, Nutraceutical and Health Endorsing Perspectives of Saffron
topicSaffron Skin Health Randomized Trial
claimCrocus sativus C. sativus C. sativus C. sativus 2019 2006 Saffron, also known asL., is a popular herbal remedy widely grown in India, Iran, and the Mediterranean.
evidence level3
citationTufail Tabussam (2025)
sourceFunctional, Nutraceutical and Health Endorsing Perspectives of Saffron

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Source documents

  1. The effects of a saffron extract (Affron®) on mood, sleep, self-esteem, and exploratory measures of physical appearance in women aged 50 to 70 years experiencing low mood and poor sleep: a randomised, double-blind, placebo-controlled trial.
  2. Functional, Nutraceutical and Health Endorsing Perspectives of Saffron