topicSaffron Mood Randomized Trial
claimAlthough these products are available without a prescription and are generally thought to be safe, there are pharmacological and toxicological risks associated with their use [].
evidence level3
citationCăuș Maria-Nina (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks
topicSaffron Mood Randomized Trial
claimThe differences in the regulatory framework allow for broad consumer access to plant-based products; it also creates potential gaps in safety monitoring and risk communication.
evidence level3
citationCăuș Maria-Nina (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks
topicSaffron Mood Randomized Trial
claimWithout strict regulations, there is a risk that food supplements may interact with prescribed medications, cause unexpected side effects, or be contaminated with harmful substances, including heavy metals, pesticides, and pathogenic microorganisms [].
evidence level3
citationCăuș Maria-Nina (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks
topicSaffron Mood Randomized Trial
claim1 Supplements based on plant extracts are frequently used to treat anxiety, depression symptoms and sleep disorders.
evidence level3
citationCăuș Maria-Nina (2026)
sourceEfficacy and Safety of Herbal Supplements with Anxiolytic, Antidepressant, and Sedative Action: A Review of Clinical Data and Toxicological Risks
topicSaffron Mood Randomized Trial
claimIt is often considered as one of the most intense experiences a woman may endure.Consequently, the fear of this pain contributes to an increased preference for cesarean delivery.It triggers increased fear and anxiety, which signals the sympathetic nervous system into a fight-or-flight response.
evidence level4
citationAlshdefat Aisha (2026)
sourceSaffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review
topicSaffron Mood Randomized Trial
claim6 7 , Medical conditions associated with prolonged labor increase the maternal mortality rate, particularly in developing countries.
evidence level4
citationAlshdefat Aisha (2026)
sourceSaffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review
topicSaffron Mood Randomized Trial
claim8 10 – 11 12 , Maternal healthcare demands reduced labor duration and pain severity.
evidence level4
citationAlshdefat Aisha (2026)
sourceSaffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review
topicSaffron Mood Randomized Trial
claim4 5 However, this response suppresses the release of oxytocin, which impacts the labor process, often increasing its duration and subsequently adding more pain.Prolonged labor is also reported when fear and pain collectively lead to reactive pelvic floor muscle contraction.
evidence level4
citationAlshdefat Aisha (2026)
sourceSaffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review