topicSaffron Depressive Symptoms Meta-Analysis
claimDifficulties in accessing healthcare, their high costs, personal preferences, and the perceived safety of medicinal herbs have contributed to the increased usage of herbalism [,,].
evidence level1
citationHasheminasab Fatemeh Sadat (2026)
sourceAdverse Events of Saffron ( Crocus sativus L.): Systematic Review of Current Evidence
topicSaffron Depressive Symptoms Meta-Analysis
claimGiven their popularity, it is crucial to have up‐to‐date risk and benefit assessments on these herbal products [].
evidence level1
citationHasheminasab Fatemeh Sadat (2026)
sourceAdverse Events of Saffron ( Crocus sativus L.): Systematic Review of Current Evidence
topicSaffron Depressive Symptoms Meta-Analysis
claimTherefore, compiling a systematic review of human studies with the aim of summarizing the available evidence on the side effects ofnot only fills the gap in the literature but also seems essential for physicians, researchers, and health policymakers to use this widely used medicinal plant safely and rationally.
evidence level1
citationHasheminasab Fatemeh Sadat (2026)
sourceAdverse Events of Saffron ( Crocus sativus L.): Systematic Review of Current Evidence
topicSaffron Depressive Symptoms Meta-Analysis
claimsativus 1 1 2 2 3 Saffron (L.) is a sophisticated spice with culinary and therapeutic importance [].
evidence level1
citationHasheminasab Fatemeh Sadat (2026)
sourceAdverse Events of Saffron ( Crocus sativus L.): Systematic Review of Current Evidence
topicSaffron Depressive Symptoms Meta-Analysis
claim1 2 Depression is a leading cause of disability worldwide and is characterised by sustained low mood, anhedonia, anergia, and a range of associated cognitive and somatic symptoms [].
evidence level4
citationMuacevic Alexander (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review
topicSaffron Depressive Symptoms Meta-Analysis
claimThis literature review summarises key randomised controlled trials (RCTs), meta-analyses, safety data, dosing patterns, and guideline positioning for saffron in depressive disorders, with emphasis on adult major depressive disorder (MDD) and related depressive symptomatology.
evidence level4
citationMuacevic Alexander (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review
topicSaffron Depressive Symptoms Meta-Analysis
claimMethods Crocus sativus' Databases and search strategy: A targeted search was undertaken in PubMed (primary database), with supplementary searching via Google Scholar and reference-list screening of key trials and evidence syntheses included in the bibliography.
evidence level4
citationMuacevic Alexander (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review
topicSaffron Depressive Symptoms Meta-Analysis
claimAlthough standard first-line approaches, such as lifestyle interventions, psychotherapy, and antidepressant medication, are effective for many patients, a meaningful minority experience partial response, intolerable adverse effects, or poor adherence [].
evidence level4
citationMuacevic Alexander (2026)
sourceThe Role of Saffron in the Treatment of Depression: A Literature Review