Saffron Cognitive Performance Meta-Analysis Evidence Table

Structured evidence table for Saffron Cognitive Performance Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Saffron Cognitive Performance Meta-AnalysisIn general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate.1Ho Chao-Yen (2026)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
Saffron Cognitive Performance Meta-AnalysisThe analysis revealed a pooled SMD (pSMD) = 1.20 (95 % confidence interval [CI]: 0.64 to 1.76), indicating that taking herbal dietary supplements was associated with a greater improvement in erectile function as compared to controls.1Ho Chao-Yen (2026)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
Saffron Cognitive Performance Meta-AnalysisSaffron (pSMD = 2.23, 95 % CI: 1.66 to 2.80) and ginseng (pSMD = 0.41, 95 % CI: 0.20 to 0.62) were each significantly associated with greater improvement in ED compared to that of controls, whereaswas shown to have positive effects on ED compared to controls, but the difference was not statistically significant (pSMD = 0.74, 95 % CI: −0.24 to 1.72).1Ho Chao-Yen (2026)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
Saffron Cognitive Performance Meta-AnalysisIncidence of ED is reported to increase with increasing age.An estimated 8.3 % of insured men in the United States have been diagnosed with ED, translating to approximately 10.3 million men seeking care for this condition as of 2022.1Ho Chao-Yen (2026)Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
Saffron Cognitive Performance Meta-AnalysisIn recent years, a growing body of scientific evidence supporting several of these traditional uses has shown the potential of saffron and its main ingredients—crocins, crocetin, safranal, and picrocrocin—as pharmacologically relevant compounds.3Campos Catarina (2026)From Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
Saffron Cognitive Performance Meta-AnalysisBy integrating evidence from in vitro studies, animal models, and clinical trials, this review critically assesses saffron’s potential as a multi-target pharmacological agent and identifies key limitations and future directions for its development within pharmaceutical and integrative medicine frameworks.3Campos Catarina (2026)From Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
Saffron Cognitive Performance Meta-AnalysisConsidering the scope of disease areas covered, this review is intended to be a broad narrative overview rather than an exhaustive systematic evaluation of each disease, with a focus on critically evaluating study quality, level of evidence, gaps between preclinical findings and clinical applicability, and limitations across sections.3Campos Catarina (2026)From Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
Saffron Cognitive Performance Meta-AnalysisCrocus sativus 1 2 3 4 5 6 Natural products remain one of the main sources of pharmacologically bioactive compounds (BACs) and have played a fundamental role in the development of new drugs.3Campos Catarina (2026)From Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
topicSaffron Cognitive Performance Meta-Analysis
claimIn general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicSaffron Cognitive Performance Meta-Analysis
claimThe analysis revealed a pooled SMD (pSMD) = 1.20 (95 % confidence interval [CI]: 0.64 to 1.76), indicating that taking herbal dietary supplements was associated with a greater improvement in erectile function as compared to controls.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicSaffron Cognitive Performance Meta-Analysis
claimSaffron (pSMD = 2.23, 95 % CI: 1.66 to 2.80) and ginseng (pSMD = 0.41, 95 % CI: 0.20 to 0.62) were each significantly associated with greater improvement in ED compared to that of controls, whereaswas shown to have positive effects on ED compared to controls, but the difference was not statistically significant (pSMD = 0.74, 95 % CI: −0.24 to 1.72).
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicSaffron Cognitive Performance Meta-Analysis
claimIncidence of ED is reported to increase with increasing age.An estimated 8.3 % of insured men in the United States have been diagnosed with ED, translating to approximately 10.3 million men seeking care for this condition as of 2022.
evidence level1
citationHo Chao-Yen (2026)
sourceHerbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
topicSaffron Cognitive Performance Meta-Analysis
claimIn recent years, a growing body of scientific evidence supporting several of these traditional uses has shown the potential of saffron and its main ingredients—crocins, crocetin, safranal, and picrocrocin—as pharmacologically relevant compounds.
evidence level3
citationCampos Catarina (2026)
sourceFrom Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
topicSaffron Cognitive Performance Meta-Analysis
claimBy integrating evidence from in vitro studies, animal models, and clinical trials, this review critically assesses saffron’s potential as a multi-target pharmacological agent and identifies key limitations and future directions for its development within pharmaceutical and integrative medicine frameworks.
evidence level3
citationCampos Catarina (2026)
sourceFrom Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
topicSaffron Cognitive Performance Meta-Analysis
claimConsidering the scope of disease areas covered, this review is intended to be a broad narrative overview rather than an exhaustive systematic evaluation of each disease, with a focus on critically evaluating study quality, level of evidence, gaps between preclinical findings and clinical applicability, and limitations across sections.
evidence level3
citationCampos Catarina (2026)
sourceFrom Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases
topicSaffron Cognitive Performance Meta-Analysis
claimCrocus sativus 1 2 3 4 5 6 Natural products remain one of the main sources of pharmacologically bioactive compounds (BACs) and have played a fundamental role in the development of new drugs.
evidence level3
citationCampos Catarina (2026)
sourceFrom Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases

Source documents

  1. Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
  2. From Stigma to Therapy: Pharmacological Insights into Saffron Bioactives for Major Non-Communicable Diseases