Structured evidence table for Safflower Oil Blood Pressure Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Safflower Oil Blood Pressure Meta-Analysis | This systematic review and meta-analysis evaluated the impact of VCO on key cardiometabolic risk factors in adults. | 1 | Zhang Y (2025) | The effect of virgin coconut oil (VCO) on cardiovascular disease risk factors: a systematic review and meta-analysis. |
| Safflower Oil Blood Pressure Meta-Analysis | Pooled analyses showed that VCO significantly reduced triglycerides (WMD: - 12.12 mg/dL; 95% CI: - 23.14 to - 1.09) and increased high density lipoprotein-cholesterol (HDL-C) (WMD: 7.91 mg/dL; 95% CI: 4.41 to 11.40). | 1 | Zhang Y (2025) | The effect of virgin coconut oil (VCO) on cardiovascular disease risk factors: a systematic review and meta-analysis. |
| Safflower Oil Blood Pressure Meta-Analysis | Assessment of publication bias using funnel plots and Egger's test indicated no significant evidence of bias. | 1 | Zhang Y (2025) | The effect of virgin coconut oil (VCO) on cardiovascular disease risk factors: a systematic review and meta-analysis. |
| Safflower Oil Blood Pressure Meta-Analysis | Background Cardiometabolic disorders remain a leading cause of morbidity and mortality worldwide. | 1 | Zhang Y (2025) | The effect of virgin coconut oil (VCO) on cardiovascular disease risk factors: a systematic review and meta-analysis. |
| Safflower Oil Blood Pressure Meta-Analysis | Increased dietary LA has contributed to a pervasive imbalance in dietary-6 relative to-3 polyunsaturated fatty acids (PUFA) that has been proposed to affect the incidence and progression of chronic diseases [,,]. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Safflower Oil Blood Pressure Meta-Analysis | 13 14 15 16 17 18 19 20 n n n n n n Early guidance to increase dietary LA stemmed from the diet–heart hypothesis of the 1960s–1970s, which proposed that replacing saturated fats with LA-rich vegetable oils would lower serum cholesterol, thereby reducing the risk of atherosclerosis and coronary heart disease. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Safflower Oil Blood Pressure Meta-Analysis | A re-analysis of the Sydney Diet Heart Study showed that replacing saturated fat with high-LA safflower oil markedly increased all-cause and cardiovascular mortality despite lowering cholesterol []. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
| Safflower Oil Blood Pressure Meta-Analysis | 1 2 3 4 5 6 7 8 9 10 11 12 n n n Over the past century, shifts in agricultural practices toward the industrial production of commodity crops, particularly soybeans and corn, have transformed the global food supply and sparked a scientific and public health debate [,,,]. | 2 | Sergeant Susan (2026) | Effect of Dietary Linoleic Acid Intake on Eicosapentaenoic Acid Status and Lipoxygenase-Mediated Oxylipin Biosynthesis in Healthy Adults: A Randomized Controlled Trial |
Source documents