topicRosemary Cognitive Performance Meta-Analysis
claimIn the late-onset groups, the apolipoprotein E (APOE) gene, the strongest and most consistently replicated genetic risk factor, is associated with AD.
evidence level3
citationLawal Rasheedat (2026)
sourceInteractions Between Blood Nutritional Biomarkers and Apolipoprotein E ε4 in the Progression of Mild Cognitive Impairment in Alzheimer’s Disease
topicRosemary Cognitive Performance Meta-Analysis
claimThe ε4 allele increases the likelihood of developing AD and is associated with greater neuroinflammation and impaired lipid transport [].
evidence level3
citationLawal Rasheedat (2026)
sourceInteractions Between Blood Nutritional Biomarkers and Apolipoprotein E ε4 in the Progression of Mild Cognitive Impairment in Alzheimer’s Disease
topicRosemary Cognitive Performance Meta-Analysis
claim2 16 17 18 14 19 18 Although individuals with MCI face an elevated risk of progression to Alzheimer’s disease [,,], if not controlled properly [], the trajectories are highly variable.
evidence level3
citationLawal Rasheedat (2026)
sourceInteractions Between Blood Nutritional Biomarkers and Apolipoprotein E ε4 in the Progression of Mild Cognitive Impairment in Alzheimer’s Disease
topicRosemary Cognitive Performance Meta-Analysis
claim1 2 3 4 Alzheimer’s disease (AD) is the most common cause of dementia [], which accounts for 55.2 million dementia cases estimated globally and is projected to exceed 75.6 million cases by 2030 [].
evidence level3
citationLawal Rasheedat (2026)
sourceInteractions Between Blood Nutritional Biomarkers and Apolipoprotein E ε4 in the Progression of Mild Cognitive Impairment in Alzheimer’s Disease
topicRosemary Cognitive Performance Meta-Analysis
claimThis study consolidates the evidence based on phytochemicals for cognitive enhancement, highlighting a need for more robust, methodologically sound trials to determine if these natural compounds hold promise in cognitive therapeutics, particularly for populations with cognitive impairments.
evidence level3
citationMarsh Alexander (2026)
sourceThe efficacy of nutritional phytochemical compounds in improving cognition
topicRosemary Cognitive Performance Meta-Analysis
claimAccordingly, this review prespecified phytochemicals that meet 3 criteria: long-standing traditional association with cognition, biological plausibility supported by preclinical evidence, and progression into human research or commercial cognitive-health formulations, includingL.
evidence level3
citationMarsh Alexander (2026)
sourceThe efficacy of nutritional phytochemical compounds in improving cognition
topicRosemary Cognitive Performance Meta-Analysis
claimWhile the evidence surrounding green tea and its relevant constituents is relatively well summarized, the impact that other herbs and phytochemical compounds may have on cognition remains to be systematically reviewed.
evidence level3
citationMarsh Alexander (2026)
sourceThe efficacy of nutritional phytochemical compounds in improving cognition
topicRosemary Cognitive Performance Meta-Analysis
claimtenuiflorum This study addresses the effectiveness of various naturally occurring molecules in improving cognitive functions in healthy adults.
evidence level3
citationMarsh Alexander (2026)
sourceThe efficacy of nutritional phytochemical compounds in improving cognition