topicRosehip Osteoarthritis Meta-Analysis
claimIt causes chronic pain, reduced mobility, and disability, affecting 607 million individuals worldwide, with nearly 46.6 million new cases annually [].
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicRosehip Osteoarthritis Meta-Analysis
claim11 12 13 14 15 11 15 HLA-DRB1 HLA-DQB1 Genetic polymorphisms in sterol regulatory element-binding protein 2 (rs2228314) [], interleukin-6 (rs1800795) [], and resistin (RETN) [] in Indian and Pakistani cohorts and growth differentiation factor 5 (rs143383) [],, andin Thai populations [] are linked to OA risk.
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicRosehip Osteoarthritis Meta-Analysis
claimNeed for expert opinion Despite growing clinical and mechanistic evidence for collagen supplementation in OA, several gaps and challenges remain in translating this knowledge into clinical practice, especially in the Indian subcontinent and Southeast Asia.
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicRosehip Osteoarthritis Meta-Analysis
claim1 2 3 4 6 7 8 9 10 1 Osteoarthritis (OA) is the most prevalent degenerative joint disease globally and the second most common rheumatologic condition [].
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicRosehip Osteoarthritis Meta-Analysis
claim1 2 [3] [4] [5] Physical activity and pharmacological treatment are both well-established, evidence-based interventions for managing osteoarthritis (OA)-related symptoms.
evidence level4
citationDahlberg Leif E. (2026)
sourceBaseline pain medication is associated with longer duration of high adherence in a three-month digital treatment program for hip and knee osteoarthritis
topicRosehip Osteoarthritis Meta-Analysis
claimInternational guidelines consistently recommend exercise and education as first-line OA management with the addition of pharmacological support as needed [,].
evidence level4
citationDahlberg Leif E. (2026)
sourceBaseline pain medication is associated with longer duration of high adherence in a three-month digital treatment program for hip and knee osteoarthritis
topicRosehip Osteoarthritis Meta-Analysis
claimClinical studies have shown that digital therapy providing evidence-based OA treatment via an app are associated with clinically meaningful reductions in pain, improved physical function, improved symptom state, and in some cases a reduced need for joint replacement surgery [,,].
evidence level4
citationDahlberg Leif E. (2026)
sourceBaseline pain medication is associated with longer duration of high adherence in a three-month digital treatment program for hip and knee osteoarthritis