topicResveratrol Mood Randomized Trial
claimFurthermore, MDD is linked to a higher risk of developing other conditions like diabetes, heart disease, and stroke, which add to its overall impact on health ().
evidence level3
citationZhu Shiyu (2026)
sourceExploring the potential of polyphenols in major depression: from molecular function to clinical therapy
topicResveratrol Mood Randomized Trial
claimNeuroimaging studies have identified key pathological features of MDD, including reduced structural volumes in both cortical and subcortical areas, decreased gray matter volume, and significant alterations in the size and density of microglial cells (,).
evidence level3
citationZhu Shiyu (2026)
sourceExploring the potential of polyphenols in major depression: from molecular function to clinical therapy
topicResveratrol Mood Randomized Trial
claimThese changes are also associated with abnormal neurotransmitter regulation and disruptions in gut microbiota ().
evidence level3
citationZhu Shiyu (2026)
sourceExploring the potential of polyphenols in major depression: from molecular function to clinical therapy
topicResveratrol Mood Randomized Trial
claim1 2 3 4 5 6 7 8 9 10 11 12 Major depressive disorder (MDD) is a prevalent psychiatric condition impacting approximately 185 million individuals worldwide ().
evidence level3
citationZhu Shiyu (2026)
sourceExploring the potential of polyphenols in major depression: from molecular function to clinical therapy
topicResveratrol Mood Randomized Trial
claimProbiotic and Dietary Supplements Intervention in Age-Related Neurodegenerative Disorders
evidence level4
citationD’Anniballe De Salles C (2026)
sourceProbiotic and Dietary Supplements Intervention in Age-Related Neurodegenerative Disorders