topicQuercetin Skin Randomized Trial
claimSystemic corticosteroid therapy effectively reduces recurrence rates; however, the severe adverse effects associated with long-term systemic corticosteroid use may outweigh the benefits for RAS patients () ().
evidence level3
citationKong Xiangran (2026)
sourceAdvances in the treatment of recurrent aphthous stomatitis: from synthetic and natural drugs to novel drug delivery systems
topicQuercetin Skin Randomized Trial
claimNotably, the role of local anesthetics (such as lidocaine) in RAS treatment is currently limited to symptomatic pain relief; there is insufficient evidence to suggest that they can alter disease progression, promote ulcer healing, or prevent recurrence ().
evidence level3
citationKong Xiangran (2026)
sourceAdvances in the treatment of recurrent aphthous stomatitis: from synthetic and natural drugs to novel drug delivery systems
topicQuercetin Skin Randomized Trial
claimTopical application of antibiotics, including tetracyclines (e.g., doxycycline, minocycline) and penicillin preparations, can result in lower pain scores, smaller ulcers, and a significant reduction in the healing cycle ().
evidence level3
citationKong Xiangran (2026)
sourceAdvances in the treatment of recurrent aphthous stomatitis: from synthetic and natural drugs to novel drug delivery systems
topicQuercetin Skin Randomized Trial
claimEpidemiological studies indicate a prevalence ranging from 5% to 66% across different countries ().
evidence level3
citationKong Xiangran (2026)
sourceAdvances in the treatment of recurrent aphthous stomatitis: from synthetic and natural drugs to novel drug delivery systems
topicQuercetin Skin Randomized Trial
claimCurrent therapies mainly alleviate symptoms without addressing underlying immune dysfunction, which has increased interest in nutritional bioactive compounds as preventive or modulatory agents.
evidence level3
citationZafrilla P (2025)
sourceDietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
topicQuercetin Skin Randomized Trial
claimThis review summarizes evidence on omega-3 polyunsaturated fatty acids, vitamin D, curcumin, ginger bioactives, quercetin, and epigallocatechin gallate (EGCG) in allergy prevention and management.
evidence level3
citationZafrilla P (2025)
sourceDietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
topicQuercetin Skin Randomized Trial
claimGinger constituents ([6]-gingerol, [6]-shogaol) modulate Th1/Th2 balance, mast-cell activity, and oxidative stress, with early clinical evidence in rhinitis and asthma.
evidence level3
citationZafrilla P (2025)
sourceDietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.
topicQuercetin Skin Randomized Trial
claimBackground/Objectives: Allergic diseases are highly prevalent worldwide and represent a significant public health burden.
evidence level3
citationZafrilla P (2025)
sourceDietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.