evidence table

Protein Satiety Meta-Analysis Evidence Table

Structured evidence table for Protein Satiety Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Protein Satiety Meta-AnalysisCapsaicin was found to increase EE and fat oxidation, particularly at high doses, although results on the possible reduction in EI were mixed.In the present narrative review and updated meta-analysis, we evaluated whether culinary doses of RP can attenuate adaptive thermogenesis and decreased fullness during negative EB in humans.3Ludy Mary-Jon (2026)Attenuation of Adaptive Thermogenesis by a Culinary Dose of Red Pepper During 24-Hour Negative Energy Balance
Protein Satiety Meta-AnalysisOverall, long-term capsaicin consumption in free-living conditions did not provide statistically significant evidence for an EE increase but did significantly reduce RQ, suggesting sustained higher fat oxidation.3Ludy Mary-Jon (2026)Attenuation of Adaptive Thermogenesis by a Culinary Dose of Red Pepper During 24-Hour Negative Energy Balance
Protein Satiety Meta-AnalysisSubgroup analysis by EB showed that capsaicin significantly increased EE in controlled EB (SMD = 0.74; 95% CI, 0.25 to 1.24), while the increase in EE during controlled negative EB did not reach statistical significance (SMD = 0.90; 95% CI, –0.13 to 1.94) ().3Ludy Mary-Jon (2026)Attenuation of Adaptive Thermogenesis by a Culinary Dose of Red Pepper During 24-Hour Negative Energy Balance
Protein Satiety Meta-AnalysisRelatively higher protein diets, which reduce total EI by lowering fat and carbohydrate intake, have shown benefits such as sustained satiety, preserved FFM, and sustained EE that counteract adaptive thermogenesis.3Ludy Mary-Jon (2026)Attenuation of Adaptive Thermogenesis by a Culinary Dose of Red Pepper During 24-Hour Negative Energy Balance
Protein Satiety Meta-AnalysisRandomized clinical trials consistently report mean weight loss ranging from approximately 15% to more than 20% of total body weight, accompanied by improvements in glycemic control, cardiometabolic risk factors, and obesity-related comorbidities [,,].3Zambrano-Villacres Raynier (2026)Nutrition-First Support for GLP-1 and Dual Incretin Therapy in Obesity: A Practical Framework for Dietary Management, Symptom Tolerability, and Long-Term Weight Maintenance
Protein Satiety Meta-AnalysisAs a result, pharmacotherapy is increasingly positioned as an important component of contemporary obesity treatment algorithms rather than a secondary or last-line option [].3Zambrano-Villacres Raynier (2026)Nutrition-First Support for GLP-1 and Dual Incretin Therapy in Obesity: A Practical Framework for Dietary Management, Symptom Tolerability, and Long-Term Weight Maintenance
Protein Satiety Meta-Analysis20 20 20 21 22 23 24 25 26 Emerging real-world evidence indicates that a substantial proportion of individuals initiating GLP-1 receptor agonist therapy discontinue treatment within the first year [].3Zambrano-Villacres Raynier (2026)Nutrition-First Support for GLP-1 and Dual Incretin Therapy in Obesity: A Practical Framework for Dietary Management, Symptom Tolerability, and Long-Term Weight Maintenance
Protein Satiety Meta-Analysis1 2 3 4 5 6 7 8 9 The therapeutic landscape of obesity management has changed profoundly with the clinical introduction and rapid uptake of glucagon-like peptide-1 (GLP-1) receptor agonists and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists (GLP-1RAs) [,].3Zambrano-Villacres Raynier (2026)Nutrition-First Support for GLP-1 and Dual Incretin Therapy in Obesity: A Practical Framework for Dietary Management, Symptom Tolerability, and Long-Term Weight Maintenance
topicProtein Satiety Meta-Analysis
claimCapsaicin was found to increase EE and fat oxidation, particularly at high doses, although results on the possible reduction in EI were mixed.In the present narrative review and updated meta-analysis, we evaluated whether culinary doses of RP can attenuate adaptive thermogenesis and decreased fullness during negative EB in humans.
evidence level3
citationLudy Mary-Jon (2026)
sourceAttenuation of Adaptive Thermogenesis by a Culinary Dose of Red Pepper During 24-Hour Negative Energy Balance
topicProtein Satiety Meta-Analysis
claimOverall, long-term capsaicin consumption in free-living conditions did not provide statistically significant evidence for an EE increase but did significantly reduce RQ, suggesting sustained higher fat oxidation.
evidence level3
citationLudy Mary-Jon (2026)
sourceAttenuation of Adaptive Thermogenesis by a Culinary Dose of Red Pepper During 24-Hour Negative Energy Balance
topicProtein Satiety Meta-Analysis
claimSubgroup analysis by EB showed that capsaicin significantly increased EE in controlled EB (SMD = 0.74; 95% CI, 0.25 to 1.24), while the increase in EE during controlled negative EB did not reach statistical significance (SMD = 0.90; 95% CI, –0.13 to 1.94) ().
evidence level3
citationLudy Mary-Jon (2026)
sourceAttenuation of Adaptive Thermogenesis by a Culinary Dose of Red Pepper During 24-Hour Negative Energy Balance
topicProtein Satiety Meta-Analysis
claimRelatively higher protein diets, which reduce total EI by lowering fat and carbohydrate intake, have shown benefits such as sustained satiety, preserved FFM, and sustained EE that counteract adaptive thermogenesis.
evidence level3
citationLudy Mary-Jon (2026)
sourceAttenuation of Adaptive Thermogenesis by a Culinary Dose of Red Pepper During 24-Hour Negative Energy Balance
topicProtein Satiety Meta-Analysis
claimRandomized clinical trials consistently report mean weight loss ranging from approximately 15% to more than 20% of total body weight, accompanied by improvements in glycemic control, cardiometabolic risk factors, and obesity-related comorbidities [,,].
evidence level3
citationZambrano-Villacres Raynier (2026)
sourceNutrition-First Support for GLP-1 and Dual Incretin Therapy in Obesity: A Practical Framework for Dietary Management, Symptom Tolerability, and Long-Term Weight Maintenance
topicProtein Satiety Meta-Analysis
claimAs a result, pharmacotherapy is increasingly positioned as an important component of contemporary obesity treatment algorithms rather than a secondary or last-line option [].
evidence level3
citationZambrano-Villacres Raynier (2026)
sourceNutrition-First Support for GLP-1 and Dual Incretin Therapy in Obesity: A Practical Framework for Dietary Management, Symptom Tolerability, and Long-Term Weight Maintenance
topicProtein Satiety Meta-Analysis
claim20 20 20 21 22 23 24 25 26 Emerging real-world evidence indicates that a substantial proportion of individuals initiating GLP-1 receptor agonist therapy discontinue treatment within the first year [].
evidence level3
citationZambrano-Villacres Raynier (2026)
sourceNutrition-First Support for GLP-1 and Dual Incretin Therapy in Obesity: A Practical Framework for Dietary Management, Symptom Tolerability, and Long-Term Weight Maintenance
topicProtein Satiety Meta-Analysis
claim1 2 3 4 5 6 7 8 9 The therapeutic landscape of obesity management has changed profoundly with the clinical introduction and rapid uptake of glucagon-like peptide-1 (GLP-1) receptor agonists and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists (GLP-1RAs) [,].
evidence level3
citationZambrano-Villacres Raynier (2026)
sourceNutrition-First Support for GLP-1 and Dual Incretin Therapy in Obesity: A Practical Framework for Dietary Management, Symptom Tolerability, and Long-Term Weight Maintenance

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Source documents

  1. Attenuation of Adaptive Thermogenesis by a Culinary Dose of Red Pepper During 24-Hour Negative Energy Balance
  2. Nutrition-First Support for GLP-1 and Dual Incretin Therapy in Obesity: A Practical Framework for Dietary Management, Symptom Tolerability, and Long-Term Weight Maintenance