Protein Muscle Synthesis Meta-Analysis Evidence Table

Structured evidence table for Protein Muscle Synthesis Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Protein Muscle Synthesis Meta-AnalysisMeta-regression explored potential moderators, and risk of bias was assessed using the ROBINS-I tool.1Kristiansen JB (2026)Age-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.
Protein Muscle Synthesis Meta-AnalysisPost-prandial MPS was also reduced in older adults (SMD = -0.348; 95% CI: -0.627 to -0.070; p = 0.014; I² = 83.4%), with consistent directionality across sensitivity analyses.1Kristiansen JB (2026)Age-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.
Protein Muscle Synthesis Meta-AnalysisEvidence for combined post-exercise MPS remains mixed, with evidence leaning toward a similar response in young and older adults.1Kristiansen JB (2026)Age-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.
Protein Muscle Synthesis Meta-AnalysisIntroduction Age-related declines in skeletal muscle mass and function are partly attributed to anabolic resistance, a diminished stimulation of muscle protein synthesis (MPS) following nutrient intake or exercise.1Kristiansen JB (2026)Age-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.
Protein Muscle Synthesis Meta-AnalysisContemporary diagnostic frameworks established by the European Working Group on Sarcopenia in Older People (EWGSOP) prioritize muscle strength assessment as the cardinal criterion, supplemented by confirmatory evidence of diminished muscle quality or quantity and compromised physical performance [].3Dharmansyah Dhika (2026)Exercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review
Protein Muscle Synthesis Meta-Analysis8 93 9 28 Emerging evidence establishes sarcopenia as a pivotal modifiable risk factor for falls.3Dharmansyah Dhika (2026)Exercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review
Protein Muscle Synthesis Meta-AnalysisThe pathophysiological linkage involves multiple mechanisms: reduced lower limb muscle strength impairs postural stability and gait control; decreased muscle mass alters center of gravity positioning; compromised neuromuscular coordination prolongs reaction times; and diminished proprioception undermines balance recovery mechanisms [,].3Dharmansyah Dhika (2026)Exercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review
Protein Muscle Synthesis Meta-Analysis1 Population aging constitutes one of the most profound demographic transformations confronting global health systems in the 21st century.3Dharmansyah Dhika (2026)Exercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review
topicProtein Muscle Synthesis Meta-Analysis
claimMeta-regression explored potential moderators, and risk of bias was assessed using the ROBINS-I tool.
evidence level1
citationKristiansen JB (2026)
sourceAge-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.
topicProtein Muscle Synthesis Meta-Analysis
claimPost-prandial MPS was also reduced in older adults (SMD = -0.348; 95% CI: -0.627 to -0.070; p = 0.014; I² = 83.4%), with consistent directionality across sensitivity analyses.
evidence level1
citationKristiansen JB (2026)
sourceAge-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.
topicProtein Muscle Synthesis Meta-Analysis
claimEvidence for combined post-exercise MPS remains mixed, with evidence leaning toward a similar response in young and older adults.
evidence level1
citationKristiansen JB (2026)
sourceAge-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.
topicProtein Muscle Synthesis Meta-Analysis
claimIntroduction Age-related declines in skeletal muscle mass and function are partly attributed to anabolic resistance, a diminished stimulation of muscle protein synthesis (MPS) following nutrient intake or exercise.
evidence level1
citationKristiansen JB (2026)
sourceAge-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.
topicProtein Muscle Synthesis Meta-Analysis
claimContemporary diagnostic frameworks established by the European Working Group on Sarcopenia in Older People (EWGSOP) prioritize muscle strength assessment as the cardinal criterion, supplemented by confirmatory evidence of diminished muscle quality or quantity and compromised physical performance [].
evidence level3
citationDharmansyah Dhika (2026)
sourceExercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review
topicProtein Muscle Synthesis Meta-Analysis
claim8 93 9 28 Emerging evidence establishes sarcopenia as a pivotal modifiable risk factor for falls.
evidence level3
citationDharmansyah Dhika (2026)
sourceExercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review
topicProtein Muscle Synthesis Meta-Analysis
claimThe pathophysiological linkage involves multiple mechanisms: reduced lower limb muscle strength impairs postural stability and gait control; decreased muscle mass alters center of gravity positioning; compromised neuromuscular coordination prolongs reaction times; and diminished proprioception undermines balance recovery mechanisms [,].
evidence level3
citationDharmansyah Dhika (2026)
sourceExercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review
topicProtein Muscle Synthesis Meta-Analysis
claim1 Population aging constitutes one of the most profound demographic transformations confronting global health systems in the 21st century.
evidence level3
citationDharmansyah Dhika (2026)
sourceExercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review

Source documents

  1. Age-related anabolic resistance and post-absorptive muscle protein synthesis: integrative evidence from a systematic review and meta-analysis.
  2. Exercise and nutritional interventions for sarcopenia-related fall prevention in older adults: An umbrella review