Structured evidence table for Probiotics Sleep Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Probiotics Sleep Randomized Trial | It is estimated that fibromyalgia can result in up to approximately 36 000$ of annual direct costs per patient in the US, imposing a considerable burden on the health care systems. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Probiotics Sleep Randomized Trial | The presence of these comorbid medical conditions can make the diagnosis of fibromyalgia challenging, which could lead to mismanagement, overtreatment, and increased drug side effects. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Probiotics Sleep Randomized Trial | Therefore, proper diagnosis of fibromyalgia and its associated comorbidities is crucial for effective management of the conditions. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Probiotics Sleep Randomized Trial | 1 2 [,] 3 [] 4 [] 5 6 [,] 7 8 [,] 7 8 [,] 5 [] Fibromyalgia is a syndrome characterized by chronic widespread musculoskeletal pain, often accompanied by a range of other symptoms, including sleep disturbances, excessive fatigue, and psychological issues such as depression. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Probiotics Sleep Randomized Trial | 6 7 8 9 Insufficient sleep and poor sleep quality are associated with daytime sleepiness and reduced performance and are also linked to increased metabolic and cardiovascular risk and adverse mental health outcomes []. | 2 | Kim Hayoung (2026) | Efficacy and Safety of Bacillus coagulans IDCC 1201 for Sleep Improvement in Adults with Sleep Disturbance: A Randomized, Double-Blind, Placebo-Controlled Polysomnographic Study |
| Probiotics Sleep Randomized Trial | However, pharmacotherapy has been consistently associated with concerns regarding adverse effects, including dependence and tolerance, withdrawal symptoms, cognitive impairment, and daytime drowsiness []. | 2 | Kim Hayoung (2026) | Efficacy and Safety of Bacillus coagulans IDCC 1201 for Sleep Improvement in Adults with Sleep Disturbance: A Randomized, Double-Blind, Placebo-Controlled Polysomnographic Study |
| Probiotics Sleep Randomized Trial | Consistent with this, emerging evidence indicates that the gut–brain axis, through bidirectional interactions between the gut microbiota and the brain, may contribute to the regulation of sleep physiology, highlighting the potential of microbiota-based interventions. | 2 | Kim Hayoung (2026) | Efficacy and Safety of Bacillus coagulans IDCC 1201 for Sleep Improvement in Adults with Sleep Disturbance: A Randomized, Double-Blind, Placebo-Controlled Polysomnographic Study |
| Probiotics Sleep Randomized Trial | 1 2 3 4 5 Sleep is an active physiological process regulated by sleep homeostasis and circadian rhythms, and it is essential for recovery and regeneration of physiological and psychological systems including at the neurochemical, hormonal, muscular and immunological levels [,]. | 2 | Kim Hayoung (2026) | Efficacy and Safety of Bacillus coagulans IDCC 1201 for Sleep Improvement in Adults with Sleep Disturbance: A Randomized, Double-Blind, Placebo-Controlled Polysomnographic Study |
Source documents