evidence table
Probiotics Depression Meta-Analysis Evidence Table
Structured evidence table for Probiotics Depression Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Probiotics Depression Meta-Analysis | Probiotic monotherapy was associated with a small but statistically significant reduction in depressive symptoms (SMD = -0.38, 95% CI: -0.57 to -0.18, p = 0.0002, I² = 51%). | 1 | Haiyan L (2026) | Efficacy of probiotic intervention in unmedicated depression: a systematic review and meta-analysis. |
| Probiotics Depression Meta-Analysis | Conclusion Probiotic monotherapy may provide modest improvement in depressive symptoms and is generally safe for unmedicated individuals with mild to moderate depression. | 1 | Haiyan L (2026) | Efficacy of probiotic intervention in unmedicated depression: a systematic review and meta-analysis. |
| Probiotics Depression Meta-Analysis | Objective To assess the independent efficacy and safety of probiotics in unmedicated adults with depression, with a focus on studies approximating monotherapy conditions. | 1 | Haiyan L (2026) | Efficacy of probiotic intervention in unmedicated depression: a systematic review and meta-analysis. |
| Probiotics Depression Meta-Analysis | Methods This systematic review and meta-analysis followed PRISMA 2020 guidelines and was registered with PROSPERO (CRD420251015474). | 1 | Haiyan L (2026) | Efficacy of probiotic intervention in unmedicated depression: a systematic review and meta-analysis. |
| Probiotics Depression Meta-Analysis | Conclusion In this randomized, double‑blind, placebo‑controlled pilot trial, both probiotic and placebo groups showed significant improvements in depressive and anxiety symptoms over time, with no significant between‑group differences. | 2 | Mosavat SH (2026) | Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial. |
| Probiotics Depression Meta-Analysis | Probiotic supplementation was associated with non‑significant trends in selected inflammatory markers, suggesting possible immunological effects that warrant further investigation. | 2 | Mosavat SH (2026) | Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial. |
| Probiotics Depression Meta-Analysis | Background Substance-Induced Depressive Disorder (SIDD) accounts for a high health burden and requires new therapies. | 2 | Mosavat SH (2026) | Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial. |
| Probiotics Depression Meta-Analysis | Bidirectional communications between the gut and the brain mediated by the microbiota point to a possible influence of probiotics as a tool for preserving mental health. | 2 | Mosavat SH (2026) | Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial. |
Source documents