Probiotic Anxiety Meta-Analysis Evidence Table

Structured evidence table for Probiotic Anxiety Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Probiotic Anxiety Meta-AnalysisMoreover, the probiotic interventions were associated with a statistically significant reduction in cortisol levels, a key biomarker of physiological stress (SMD = -0.26, 95% confidence interval [CI] [-0.45, -0.08], p = 0.005).1Ben Fredj S (2026)Probiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.
Probiotic Anxiety Meta-AnalysisHowever, due to the lack of available evidence, it was impossible to draw firm conclusions about the effects of probiotics on sleep quality and biomarkers of oxidative stress.1Ben Fredj S (2026)Probiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.
Probiotic Anxiety Meta-AnalysisConclusion This systematic review and meta-analysis provide preliminary evidence suggesting that probiotic supplementation may hold promise as an approach to improve mental well-being within working populations.1Ben Fredj S (2026)Probiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.
Probiotic Anxiety Meta-AnalysisBackground Workers face significant mental health challenges from stress, anxiety, and depression, impacting individuals, organizations, and society.1Ben Fredj S (2026)Probiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.
Probiotic Anxiety Meta-Analysis15 16 17 19 20 21 22 23 24 The emerging evidence supports that there is a bidirectional relationship between gut microbiota and depression, representing a paradigm shift in psychiatric research [,].2Mosavat Seyed Hamdollah (2026)Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial
Probiotic Anxiety Meta-AnalysisAnimal studies have presented some compelling evidence to suggest a causal role of dysbiosis in depression-like behaviours [].2Mosavat Seyed Hamdollah (2026)Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial
Probiotic Anxiety Meta-AnalysisMDD and SUD often co-occur, with each disorder increasing the risk of developing the other [].2Mosavat Seyed Hamdollah (2026)Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial
Probiotic Anxiety Meta-Analysis1 2 3 4 5 Major Depressive Disorder (MDD) is one of the most frequent and disabling psychiatric conditions worldwide, and recent estimates suggest that there are 300 million1 cases [].2Mosavat Seyed Hamdollah (2026)Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial
topicProbiotic Anxiety Meta-Analysis
claimMoreover, the probiotic interventions were associated with a statistically significant reduction in cortisol levels, a key biomarker of physiological stress (SMD = -0.26, 95% confidence interval [CI] [-0.45, -0.08], p = 0.005).
evidence level1
citationBen Fredj S (2026)
sourceProbiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.
topicProbiotic Anxiety Meta-Analysis
claimHowever, due to the lack of available evidence, it was impossible to draw firm conclusions about the effects of probiotics on sleep quality and biomarkers of oxidative stress.
evidence level1
citationBen Fredj S (2026)
sourceProbiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.
topicProbiotic Anxiety Meta-Analysis
claimConclusion This systematic review and meta-analysis provide preliminary evidence suggesting that probiotic supplementation may hold promise as an approach to improve mental well-being within working populations.
evidence level1
citationBen Fredj S (2026)
sourceProbiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.
topicProbiotic Anxiety Meta-Analysis
claimBackground Workers face significant mental health challenges from stress, anxiety, and depression, impacting individuals, organizations, and society.
evidence level1
citationBen Fredj S (2026)
sourceProbiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.
topicProbiotic Anxiety Meta-Analysis
claim15 16 17 19 20 21 22 23 24 The emerging evidence supports that there is a bidirectional relationship between gut microbiota and depression, representing a paradigm shift in psychiatric research [,].
evidence level2
citationMosavat Seyed Hamdollah (2026)
sourceEffect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial
topicProbiotic Anxiety Meta-Analysis
claimAnimal studies have presented some compelling evidence to suggest a causal role of dysbiosis in depression-like behaviours [].
evidence level2
citationMosavat Seyed Hamdollah (2026)
sourceEffect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial
topicProbiotic Anxiety Meta-Analysis
claimMDD and SUD often co-occur, with each disorder increasing the risk of developing the other [].
evidence level2
citationMosavat Seyed Hamdollah (2026)
sourceEffect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial
topicProbiotic Anxiety Meta-Analysis
claim1 2 3 4 5 Major Depressive Disorder (MDD) is one of the most frequent and disabling psychiatric conditions worldwide, and recent estimates suggest that there are 300 million1 cases [].
evidence level2
citationMosavat Seyed Hamdollah (2026)
sourceEffect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial

Source documents

  1. Probiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.
  2. Effect of probiotic supplement on improvement of depressive symptoms in patients with substance-induced depressive disorder: a randomized, double-blind, placebo-controlled clinical trial