Structured evidence table for Prebiotic Sleep Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Prebiotic Sleep Randomized Trial | It is estimated that fibromyalgia can result in up to approximately 36 000$ of annual direct costs per patient in the US, imposing a considerable burden on the health care systems. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Prebiotic Sleep Randomized Trial | The presence of these comorbid medical conditions can make the diagnosis of fibromyalgia challenging, which could lead to mismanagement, overtreatment, and increased drug side effects. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Prebiotic Sleep Randomized Trial | Therefore, proper diagnosis of fibromyalgia and its associated comorbidities is crucial for effective management of the conditions. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Prebiotic Sleep Randomized Trial | 1 2 [,] 3 [] 4 [] 5 6 [,] 7 8 [,] 7 8 [,] 5 [] Fibromyalgia is a syndrome characterized by chronic widespread musculoskeletal pain, often accompanied by a range of other symptoms, including sleep disturbances, excessive fatigue, and psychological issues such as depression. | 1 | Nakhostin-Ansari Amin (2026) | Effects of probiotics on psychological issues in people with fibromyalgia: a systematic review |
| Prebiotic Sleep Randomized Trial | Disturbances in sleep have been associated with shifts in gut microbiome composition, but this relationship remains incompletely understood and it suggests a bidirectional nature. | 3 | Borrego-Ruiz A (2026) | The Gut Microbiome in Sleep Disorders: A Review of Recent Evidence. |
| Prebiotic Sleep Randomized Trial | Evidence indicates that interventions targeting the gut microbiome, such as the use of psychobiotics and fecal microbiota transplantation, may have potential for improving sleep outcomes, but further research is needed to determine their actual effectiveness. | 3 | Borrego-Ruiz A (2026) | The Gut Microbiome in Sleep Disorders: A Review of Recent Evidence. |
| Prebiotic Sleep Randomized Trial | Alterations in the gut microbiome have been shown to influence sleep through gut-brain interactions. | 3 | Borrego-Ruiz A (2026) | The Gut Microbiome in Sleep Disorders: A Review of Recent Evidence. |
| Prebiotic Sleep Randomized Trial | However, the interplay between the gut microbiome and sleep disorders remains insufficiently understood. | 3 | Borrego-Ruiz A (2026) | The Gut Microbiome in Sleep Disorders: A Review of Recent Evidence. |
Source documents