topicPrebiotic Constipation Meta-Analysis
claimDesigned as a narrative review employing systematic search strategies to ensure comprehensive coverage while accommodating evidence heterogeneity, this study evaluates the efficacy and safety of probiotics, prebiotics, and synbiotics (PP/S) in FC with comorbid depression.
evidence level4
citationDai Q (2026)
sourceResearch progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review.
topicPrebiotic Constipation Meta-Analysis
claimUsing the terms "probiotic/prebiotic/synbiotic," "functional constipation," and "depression" as subject headings and free-text keywords, we analyzed the available evidence.
evidence level4
citationDai Q (2026)
sourceResearch progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review.
topicPrebiotic Constipation Meta-Analysis
claimCurrent evidence suggests that, in adults (including some older adults), PP/S are associated with improvements in spontaneous bowel movements and stool form (Bristol Stool Form Scale), alongside reductions in abdominal symptoms.
evidence level4
citationDai Q (2026)
sourceResearch progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review.
topicPrebiotic Constipation Meta-Analysis
claimFunctional constipation (FC) commonly co-occurs with depression, with the microbiota-gut-brain axis providing a biological basis for this association.
evidence level4
citationDai Q (2026)
sourceResearch progress and controversies in the treatment of functional constipation-related depression with probiotics and prebiotics: a narrative review.