topicPomegranate Sleep Quality Randomized Trial
claimConclusion In conclusion, a novel PB showed promise for attenuating muscle pain and perceived exhaustion, and improving sleep quality, in the days after muscle damaging exercise.
evidence level2
citationThorley J (2026)
sourceThe Effects of a Phytochemical Supplement Blend on Markers of Exercise-Induced Muscle Damage: A Randomised Controlled Trial.
topicPomegranate Sleep Quality Randomized Trial
claimBackground and objectives This study examined the effects of a novel phytochemical supplement blend on markers of exercise-induced muscle damage.
evidence level2
citationThorley J (2026)
sourceThe Effects of a Phytochemical Supplement Blend on Markers of Exercise-Induced Muscle Damage: A Randomised Controlled Trial.
topicPomegranate Sleep Quality Randomized Trial
claimMethods In a randomised, parallel group design, 24 healthy participants (14 males) consumed 300 mg of a phytochemical blend (calcium fructoborate, turmeric and pomegranate; PB) or inert placebo for 9 days (n = 12 per condition).
evidence level2
citationThorley J (2026)
sourceThe Effects of a Phytochemical Supplement Blend on Markers of Exercise-Induced Muscle Damage: A Randomised Controlled Trial.
topicPomegranate Sleep Quality Randomized Trial
claimPolyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ).
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicPomegranate Sleep Quality Randomized Trial
claimWhile many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicPomegranate Sleep Quality Randomized Trial
claimControlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicPomegranate Sleep Quality Randomized Trial
claimAMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities