topicPolypodium Leucotomos Skin Hydration Meta-Analysis
claimResults We found a total of 21 clinical trials examining the effectiveness of herbal remedies in treating melasma.
evidence level2
citationParvizi MM (2024)
sourceClinical Trials Conducted on Herbal Remedies for the Treatment of Melasma: A Scoping Review.
topicPolypodium Leucotomos Skin Hydration Meta-Analysis
claimConclusion Few studies have evaluated the effectiveness of herbal remedies in treating melasma.
evidence level2
citationParvizi MM (2024)
sourceClinical Trials Conducted on Herbal Remedies for the Treatment of Melasma: A Scoping Review.
topicPolypodium Leucotomos Skin Hydration Meta-Analysis
claimIntroduction Melasma, also known as chloasma, is a common skin disorder characterized by acquired hyperpigmentation.
evidence level2
citationParvizi MM (2024)
sourceClinical Trials Conducted on Herbal Remedies for the Treatment of Melasma: A Scoping Review.
topicPolypodium Leucotomos Skin Hydration Meta-Analysis
claimMany patients with this condition prefer using herbal remedies instead of chemical agents.
evidence level2
citationParvizi MM (2024)
sourceClinical Trials Conducted on Herbal Remedies for the Treatment of Melasma: A Scoping Review.
topicPolypodium Leucotomos Skin Hydration Meta-Analysis
claimThis latter aspect, associated with the concept of dysfunctional tissue regeneration or incomplete damage overcome, is largely underestimated.
evidence level3
citationAprile Noemi (2026)
sourceTargeting Oxidative Stress to Treat Vitiligo: Clinical and Molecular Evidence
topicPolypodium Leucotomos Skin Hydration Meta-Analysis
claimStratum corneum hydration is significantly reduced in involved skin compared to non-involved areas and keratinocytes differentiation is deregulated, leading to altered lipid composition, including imbalances in cholesterol, free fatty acids, and ceramides essential for barrier integrity [].
evidence level3
citationAprile Noemi (2026)
sourceTargeting Oxidative Stress to Treat Vitiligo: Clinical and Molecular Evidence
topicPolypodium Leucotomos Skin Hydration Meta-Analysis
claimVitiligo can be classified, according to Vitiligo Global Issues Consensus Conference (VGICC), as segmental (SV), where depigmented lesions only appear on one side of the body; non-segmental (NSV), that is further divided into generalized, acrofacial, universal, and mixed (associated with SV) types; and undetermined/unclassified vitiligo, including the focal and mucosal types [].
evidence level3
citationAprile Noemi (2026)
sourceTargeting Oxidative Stress to Treat Vitiligo: Clinical and Molecular Evidence
topicPolypodium Leucotomos Skin Hydration Meta-Analysis
claim1 2 3 4 Vitiligo is a chronic acquired autoimmune disorder characterized by the disappearance of melanocytes, the skin pigment-producing cells, leading to well-marked, oval, circular, or linear-shaped, pearly white macules and patches, varying from a few millimeters to centimeters in size and centrifugally expanded.
evidence level3
citationAprile Noemi (2026)
sourceTargeting Oxidative Stress to Treat Vitiligo: Clinical and Molecular Evidence