Structured evidence table for Plant Sterols LDL Cholesterol Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Plant Sterols LDL Cholesterol Meta-Analysis | So, maintaining low levels of LDL-c over time, following the emerging scientific consensus of ‘lower is better, and earlier is better’, could lead to a substantial reduction in ASCVD risk []. | 3 | Ferrandino Martina (2026) | Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia |
| Plant Sterols LDL Cholesterol Meta-Analysis | The aim of this narrative review is to provide an updated overview of the complex genetic architecture underlying hypercholesterolemia and increased cardiovascular risk by discussing the contribution of monogenic disorders, polygenic risk scores (PRS) and lipoprotein(a)—Lp(a)—to increased LDL-c levels (). | 3 | Ferrandino Martina (2026) | Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia |
| Plant Sterols LDL Cholesterol Meta-Analysis | This could lead to improved cardiovascular prevention with a more comprehensive and individualized approach and, consequently, better patient management. | 3 | Ferrandino Martina (2026) | Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia |
| Plant Sterols LDL Cholesterol Meta-Analysis | 1 2 Figure 1 Atherosclerotic cardiovascular disease (ASCVD) is the main cause of mortality worldwide, with low-density lipoprotein cholesterol (LDL-c) as the main driver of its pathogenesis []. | 3 | Ferrandino Martina (2026) | Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia |
| Plant Sterols LDL Cholesterol Meta-Analysis | ( ) 1 1 2 3 4 5 6 7 9 10 12 10 12 13 10 14 10 12 15 16 17 11 10 Plant sterols (PS) (including phytosterols and phytostanols) are C28 and C29-steroidal carbonic alcohols similar to cholesterolFig., being β-sitosterol, campesterol and stigmasterol those found in plants in greatest proportion. | 3 | Musto Leonardo (2026) | Overview of the effect of dietary supplementation with plant sterols on low-grade inflammation, endothelial dysfunction and oxidative stress in patients with hypercholesterolemia |
| Plant Sterols LDL Cholesterol Meta-Analysis | Vegetable oils, nuts and unrefined cereals are the main foods in which PS can be found [,]. | 3 | Musto Leonardo (2026) | Overview of the effect of dietary supplementation with plant sterols on low-grade inflammation, endothelial dysfunction and oxidative stress in patients with hypercholesterolemia |
| Plant Sterols LDL Cholesterol Meta-Analysis | 18 19 20 2 21 23 24 21 22 25 Cardiovascular disease (CVD) is currently the leading cause of death worldwide, accounting for 17.9 million deaths (32% of total deaths) in 2019 [], being hypercholesterolemia one of the main risk factors [,]. | 3 | Musto Leonardo (2026) | Overview of the effect of dietary supplementation with plant sterols on low-grade inflammation, endothelial dysfunction and oxidative stress in patients with hypercholesterolemia |
Source documents