evidence table

Phosphatidylcholine Cognition Meta-Analysis Evidence Table

Structured evidence table for Phosphatidylcholine Cognition Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Phosphatidylcholine Cognition Meta-AnalysisWe searched PubMed and Google Scholar from database inception to Dec 1, 2025, for studies in any language using the search terms (“metabolomics” OR “metabolomic profile” OR “plasma metabolites”) AND (“hip fracture” OR “osteoporosis fracture” OR “bone fracture risk”).3Wu Zhiyuan (2026)Plasma metabolomic profiles and risk of hip fracture among US individuals: a nested case–control and prospective cohort study
Phosphatidylcholine Cognition Meta-AnalysisHowever, we identified no large-scale prospective studies that systematically examined the association between a wide range of plasma metabolites and the risk of hip fracture.3Wu Zhiyuan (2026)Plasma metabolomic profiles and risk of hip fracture among US individuals: a nested case–control and prospective cohort study
Phosphatidylcholine Cognition Meta-AnalysisIn particular, the role of phospholipid metabolism in relation to hip fracture risk had not been well established.3Wu Zhiyuan (2026)Plasma metabolomic profiles and risk of hip fracture among US individuals: a nested case–control and prospective cohort study
Phosphatidylcholine Cognition Meta-AnalysisPrevious metabolomics studies have reported associations of certain metabolites with bone mineral density and osteoporosis in general.3Wu Zhiyuan (2026)Plasma metabolomic profiles and risk of hip fracture among US individuals: a nested case–control and prospective cohort study
Phosphatidylcholine Cognition Meta-AnalysisHowever, its metabolite trimethylamine N-oxide is considered a potential cardiovascular risk factor.4Wang W (2026)Association between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults.
Phosphatidylcholine Cognition Meta-AnalysisRESULTS: In the high-dose phosphatidylcholine group, serum trimethylamine N-oxide concentration increased significantly at 12 weeks (Week 12) compared with Baseline (Week 0) (P = 0.028).4Wang W (2026)Association between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults.
Phosphatidylcholine Cognition Meta-AnalysisAcross all groups, mean trimethylamine N-oxide values remained substantially below the threshold associated with high clinical risk.4Wang W (2026)Association between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults.
Phosphatidylcholine Cognition Meta-AnalysisBACKGROUND: Egg-derived phosphatidylcholine may support the maintenance of cognitive function.4Wang W (2026)Association between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults.
topicPhosphatidylcholine Cognition Meta-Analysis
claimWe searched PubMed and Google Scholar from database inception to Dec 1, 2025, for studies in any language using the search terms (“metabolomics” OR “metabolomic profile” OR “plasma metabolites”) AND (“hip fracture” OR “osteoporosis fracture” OR “bone fracture risk”).
evidence level3
citationWu Zhiyuan (2026)
sourcePlasma metabolomic profiles and risk of hip fracture among US individuals: a nested case–control and prospective cohort study
topicPhosphatidylcholine Cognition Meta-Analysis
claimHowever, we identified no large-scale prospective studies that systematically examined the association between a wide range of plasma metabolites and the risk of hip fracture.
evidence level3
citationWu Zhiyuan (2026)
sourcePlasma metabolomic profiles and risk of hip fracture among US individuals: a nested case–control and prospective cohort study
topicPhosphatidylcholine Cognition Meta-Analysis
claimIn particular, the role of phospholipid metabolism in relation to hip fracture risk had not been well established.
evidence level3
citationWu Zhiyuan (2026)
sourcePlasma metabolomic profiles and risk of hip fracture among US individuals: a nested case–control and prospective cohort study
topicPhosphatidylcholine Cognition Meta-Analysis
claimPrevious metabolomics studies have reported associations of certain metabolites with bone mineral density and osteoporosis in general.
evidence level3
citationWu Zhiyuan (2026)
sourcePlasma metabolomic profiles and risk of hip fracture among US individuals: a nested case–control and prospective cohort study
topicPhosphatidylcholine Cognition Meta-Analysis
claimHowever, its metabolite trimethylamine N-oxide is considered a potential cardiovascular risk factor.
evidence level4
citationWang W (2026)
sourceAssociation between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults.
topicPhosphatidylcholine Cognition Meta-Analysis
claimRESULTS: In the high-dose phosphatidylcholine group, serum trimethylamine N-oxide concentration increased significantly at 12 weeks (Week 12) compared with Baseline (Week 0) (P = 0.028).
evidence level4
citationWang W (2026)
sourceAssociation between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults.
topicPhosphatidylcholine Cognition Meta-Analysis
claimAcross all groups, mean trimethylamine N-oxide values remained substantially below the threshold associated with high clinical risk.
evidence level4
citationWang W (2026)
sourceAssociation between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults.
topicPhosphatidylcholine Cognition Meta-Analysis
claimBACKGROUND: Egg-derived phosphatidylcholine may support the maintenance of cognitive function.
evidence level4
citationWang W (2026)
sourceAssociation between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults.

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Source documents

  1. Plasma metabolomic profiles and risk of hip fracture among US individuals: a nested case–control and prospective cohort study
  2. Association between egg-derived phosphatidylcholine intake and trimethylamine N-oxide in healthy middle-aged and older adults.