topicPalmitoylethanolamide Joint Comfort Randomized Trial
claimDepending on disease severity, eczema is associated with several comorbid chronic health disorders, impaired quality of life, and increased healthcare dependence [].
evidence level2
citationRao Amanda (2024)
sourceEfficacy of Topical Palmitoylethanolamide (Levagen+) for the Management of Eczema Symptoms: A Double-Blind, Comparator-Controlled, Randomized Clinical Trial
topicPalmitoylethanolamide Joint Comfort Randomized Trial
claimThe complexity and numerous factors associated with eczema have made the development of therapies targeted at eczema management and relief difficult.
evidence level2
citationRao Amanda (2024)
sourceEfficacy of Topical Palmitoylethanolamide (Levagen+) for the Management of Eczema Symptoms: A Double-Blind, Comparator-Controlled, Randomized Clinical Trial
topicPalmitoylethanolamide Joint Comfort Randomized Trial
claimIn the lesional skin, mast cells interact with the nerve fibres by releasing allogenic and puritogenic mediators that result in the release of inflammatory neuropeptides thus, creating a vicious negative feedback loop [].
evidence level2
citationRao Amanda (2024)
sourceEfficacy of Topical Palmitoylethanolamide (Levagen+) for the Management of Eczema Symptoms: A Double-Blind, Comparator-Controlled, Randomized Clinical Trial
topicPalmitoylethanolamide Joint Comfort Randomized Trial
claim1 2 3 4 5 Eczema (atopic dermatitis) is a chronic, multifactorial inflammatory skin disease characterised by itchy, dry, rough, and scaling skin [].
evidence level2
citationRao Amanda (2024)
sourceEfficacy of Topical Palmitoylethanolamide (Levagen+) for the Management of Eczema Symptoms: A Double-Blind, Comparator-Controlled, Randomized Clinical Trial