skin aging

Oral Hyaluronic Acid Skin Health Randomized Trial Evidence Table

Structured evidence table for Oral Hyaluronic Acid Skin Health Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Oral Hyaluronic Acid Skin Health Randomized TrialMulti-omics analysis showed that QYG selectively remodeled gut microbiota, enriching Lactobacillus -, Bifidobacterium -, and Akkermansia -associated taxa, regulated serum metabolites related to energy and lipid metabolism, and enriched mitochondrial energy metabolism-related pathways in photoaged skin.4Yang Z (2026)Food-Medicine Homologous Qiongyu Gao Attenuates Skin Photoaging by Remodeling Gut Microbiota and Restoring Mitochondrial Energy Metabolism.
Oral Hyaluronic Acid Skin Health Randomized TrialIn fibroblasts, QYG-containing serum restored mitochondrial membrane potential, reduced ROS accumulation and cellular senescence, and regulated AMPK/PGC-1α-associated markers.4Yang Z (2026)Food-Medicine Homologous Qiongyu Gao Attenuates Skin Photoaging by Remodeling Gut Microbiota and Restoring Mitochondrial Energy Metabolism.
Oral Hyaluronic Acid Skin Health Randomized TrialThese findings support QYG as a promising food-medicine homologous functional food candidate for skin health maintenance through gut microbiota-associated systemic metabolic regulation.4Yang Z (2026)Food-Medicine Homologous Qiongyu Gao Attenuates Skin Photoaging by Remodeling Gut Microbiota and Restoring Mitochondrial Energy Metabolism.
Oral Hyaluronic Acid Skin Health Randomized TrialBioactive food ingredients that regulate the gut microbiota are promising dietary strategies for supporting systemic health, but their roles in skin photoaging remain insufficiently defined.4Yang Z (2026)Food-Medicine Homologous Qiongyu Gao Attenuates Skin Photoaging by Remodeling Gut Microbiota and Restoring Mitochondrial Energy Metabolism.
Oral Hyaluronic Acid Skin Health Randomized TrialOral SEP administration increased skin hydration and decreased TEWL, suggesting improved barrier function.4Lee C (2025)Orally Administered Edible Snail Extract Powder Enhances Skin Hydration via Hyaluronic Acid Synthesis and Barrier Gene Modulation in SKH-1 Hairless Mice.
Oral Hyaluronic Acid Skin Health Randomized TrialSKH-1 hairless mice were used as the in vivo model in this study to evaluate the efficacy of oral snail extract powder (SEP) on skin hydration and barrier enhancement.4Lee C (2025)Orally Administered Edible Snail Extract Powder Enhances Skin Hydration via Hyaluronic Acid Synthesis and Barrier Gene Modulation in SKH-1 Hairless Mice.
Oral Hyaluronic Acid Skin Health Randomized TrialThe skin serves as a primary barrier against external stimuli and plays a critical role in maintaining water homeostasis.4Lee C (2025)Orally Administered Edible Snail Extract Powder Enhances Skin Hydration via Hyaluronic Acid Synthesis and Barrier Gene Modulation in SKH-1 Hairless Mice.
topicOral Hyaluronic Acid Skin Health Randomized Trial
claimMulti-omics analysis showed that QYG selectively remodeled gut microbiota, enriching Lactobacillus -, Bifidobacterium -, and Akkermansia -associated taxa, regulated serum metabolites related to energy and lipid metabolism, and enriched mitochondrial energy metabolism-related pathways in photoaged skin.
evidence level4
citationYang Z (2026)
sourceFood-Medicine Homologous Qiongyu Gao Attenuates Skin Photoaging by Remodeling Gut Microbiota and Restoring Mitochondrial Energy Metabolism.
topicOral Hyaluronic Acid Skin Health Randomized Trial
claimIn fibroblasts, QYG-containing serum restored mitochondrial membrane potential, reduced ROS accumulation and cellular senescence, and regulated AMPK/PGC-1α-associated markers.
evidence level4
citationYang Z (2026)
sourceFood-Medicine Homologous Qiongyu Gao Attenuates Skin Photoaging by Remodeling Gut Microbiota and Restoring Mitochondrial Energy Metabolism.
topicOral Hyaluronic Acid Skin Health Randomized Trial
claimThese findings support QYG as a promising food-medicine homologous functional food candidate for skin health maintenance through gut microbiota-associated systemic metabolic regulation.
evidence level4
citationYang Z (2026)
sourceFood-Medicine Homologous Qiongyu Gao Attenuates Skin Photoaging by Remodeling Gut Microbiota and Restoring Mitochondrial Energy Metabolism.
topicOral Hyaluronic Acid Skin Health Randomized Trial
claimBioactive food ingredients that regulate the gut microbiota are promising dietary strategies for supporting systemic health, but their roles in skin photoaging remain insufficiently defined.
evidence level4
citationYang Z (2026)
sourceFood-Medicine Homologous Qiongyu Gao Attenuates Skin Photoaging by Remodeling Gut Microbiota and Restoring Mitochondrial Energy Metabolism.
topicOral Hyaluronic Acid Skin Health Randomized Trial
claimOral SEP administration increased skin hydration and decreased TEWL, suggesting improved barrier function.
evidence level4
citationLee C (2025)
sourceOrally Administered Edible Snail Extract Powder Enhances Skin Hydration via Hyaluronic Acid Synthesis and Barrier Gene Modulation in SKH-1 Hairless Mice.
topicOral Hyaluronic Acid Skin Health Randomized Trial
claimSKH-1 hairless mice were used as the in vivo model in this study to evaluate the efficacy of oral snail extract powder (SEP) on skin hydration and barrier enhancement.
evidence level4
citationLee C (2025)
sourceOrally Administered Edible Snail Extract Powder Enhances Skin Hydration via Hyaluronic Acid Synthesis and Barrier Gene Modulation in SKH-1 Hairless Mice.
topicOral Hyaluronic Acid Skin Health Randomized Trial
claimThe skin serves as a primary barrier against external stimuli and plays a critical role in maintaining water homeostasis.
evidence level4
citationLee C (2025)
sourceOrally Administered Edible Snail Extract Powder Enhances Skin Hydration via Hyaluronic Acid Synthesis and Barrier Gene Modulation in SKH-1 Hairless Mice.

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Source documents

  1. Food-Medicine Homologous Qiongyu Gao Attenuates Skin Photoaging by Remodeling Gut Microbiota and Restoring Mitochondrial Energy Metabolism.
  2. Orally Administered Edible Snail Extract Powder Enhances Skin Hydration via Hyaluronic Acid Synthesis and Barrier Gene Modulation in SKH-1 Hairless Mice.