Structured evidence table for Oral Collagen Joint Function Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Oral Collagen Joint Function Randomized Trial | WOMAC total, function, and pain scores significantly improved in patients who lost or maintained their weight compared with those who gained weight. | 4 | Bay-Jensen AC (2026) | Weight loss ameliorates symptoms of osteoarthritis and is correlated with alterations in soluble bone and cartilage markers: an analysis of patient-reported outcomes and biomarkers. |
| Oral Collagen Joint Function Randomized Trial | The bone resorption biomarker CTX-I increased by 1.58-fold [95% CI 1.39, 1.81], 1.37-fold [1.28, 1.47], and 1.11-fold [0.95, 1.28] in the weight loss, stable weight, and weight gain groups, respectively. | 4 | Bay-Jensen AC (2026) | Weight loss ameliorates symptoms of osteoarthritis and is correlated with alterations in soluble bone and cartilage markers: an analysis of patient-reported outcomes and biomarkers. |
| Oral Collagen Joint Function Randomized Trial | The cartilage degradation marker C2M increased by 1.15-fold [0.95, 1.39], whereas the interstitial matrix degradation marker C3M decreased by 0.84-fold [0.73, 0.97] in the weight loss group. | 4 | Bay-Jensen AC (2026) | Weight loss ameliorates symptoms of osteoarthritis and is correlated with alterations in soluble bone and cartilage markers: an analysis of patient-reported outcomes and biomarkers. |
| Oral Collagen Joint Function Randomized Trial | Background Drug development for osteoarthritis (OA) has faced significant challenges, mainly due to the lack of alignment between joint structure observations and patient-reported outcomes (PROs), such as pain. | 4 | Bay-Jensen AC (2026) | Weight loss ameliorates symptoms of osteoarthritis and is correlated with alterations in soluble bone and cartilage markers: an analysis of patient-reported outcomes and biomarkers. |
| Oral Collagen Joint Function Randomized Trial | With increasing consumer and clinical interest, collagen supplementation has expanded rapidly, yet scientific evidence supporting its efficacy in anti-aging and regenerative applications remains inconsistent. | 4 | Ivaskiene T (2025) | Collagen supplementation and regenerative health: advances in biomarker detection and smart material integration. |
| Oral Collagen Joint Function Randomized Trial | This review critically evaluates current evidence on oral collagen supplementation, integrating insights from over 60 clinical studies assessing its effects on skin aging, musculoskeletal health, and hair disorders. | 4 | Ivaskiene T (2025) | Collagen supplementation and regenerative health: advances in biomarker detection and smart material integration. |
| Oral Collagen Joint Function Randomized Trial | Collagen, the most abundant structural protein in the human body, plays a key role in skin integrity, tissue repair, and extracellular matrix organization. | 4 | Ivaskiene T (2025) | Collagen supplementation and regenerative health: advances in biomarker detection and smart material integration. |
Source documents