evidence table
Omega-3 Cognition Meta-Analysis Evidence Table
Structured evidence table for Omega-3 Cognition Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Omega-3 Cognition Meta-Analysis | Concurrently, the number of individuals affected by dementia is anticipated to nearly triple by 2050, with associated treatment costs projected to reach US$2.8 trillion by 2030 []. | 1 | Liu Xing (2026) | Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis |
| Omega-3 Cognition Meta-Analysis | In addition, omega-3 fatty acids support synaptic plasticity and exert anti-inflammatory effects; however, evidence is mixed, as randomized trials in healthy older adults show limited benefits [,], while several analyses report modest improvements in aged or MCI patients [,]. | 1 | Liu Xing (2026) | Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis |
| Omega-3 Cognition Meta-Analysis | Observational studies and recent trials involving antioxidant nutrients, such as pomegranate juice and resveratrol, alongside polyphenols, suggest potential protection for specific cognitive domains (e.g., memory) and reduced dementia risk, although effects are heterogeneous and causality remains unconfirmed [,]. | 1 | Liu Xing (2026) | Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis |
| Omega-3 Cognition Meta-Analysis | 1 2 3 4 5 6 7 8 9 10 The World Health Organization (WHO) projects that by 2050, the global population aged 60 and above will reach 2.1 billion, highlighting the inevitability of global aging []. | 1 | Liu Xing (2026) | Nutritional supplements and cognition in healthy aging and mild cognitive impairment patients: a systematic review and network meta-analysis |
| Omega-3 Cognition Meta-Analysis | Consequently, identifying modifiable risk factors to prevent or delay cognitive decline is of critical public health importance [,]. | 4 | Liao Zheng-Bin (2026) | The association between omega-3 supplementation and cognitive decline in older adults |
| Omega-3 Cognition Meta-Analysis | By elucidating these specific neurobiological pathways, we aim to provide clinical evidence that informs the debate regarding the role of omega-3 fatty acids supplementation in slowing cognitive decline. | 4 | Liao Zheng-Bin (2026) | The association between omega-3 supplementation and cognitive decline in older adults |
| Omega-3 Cognition Meta-Analysis | 29 30 31 This study employed three commonly used cognitive scales to assess longitudinal trajectories associated with omega-3 supplementation: the Mini-Mental State Examination (MMSE), the Alzheimer’s Disease Assessment Scale–Cognitive Subscale 13 (ADAS-Cog13), and the Clinical Dementia Rating–Sum of Boxes (CDR-SB). | 4 | Liao Zheng-Bin (2026) | The association between omega-3 supplementation and cognitive decline in older adults |
| Omega-3 Cognition Meta-Analysis | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 in vivo Alzheimer’s disease (AD), the leading cause of dementia, imposes a growing global public health burden []. | 4 | Liao Zheng-Bin (2026) | The association between omega-3 supplementation and cognitive decline in older adults |
Source documents