Structured evidence table for Nicotinamide Skin Barrier Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Nicotinamide Skin Barrier Randomized Trial | 5-min exposures produced dose-dependent EIS decline with broad suppression of barrier and immune mediators (e.g., CXCL11, MCP4, and HNMT), 6-h exposure sustained skin barrier loss and associated inflammatory and remodeling programs. | 4 | Li M (2026) | Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms. |
| Nicotinamide Skin Barrier Randomized Trial | NAC/NAM reduced SDS-induced reactive oxygen species, cytotoxicity, and permeability in primary keratinocytes, and restored EIS values in ex vivo skin. | 4 | Li M (2026) | Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms. |
| Nicotinamide Skin Barrier Randomized Trial | Conclusion Short-term SDS exposure rapidly disrupts human skin barrier integrity through oxidative stress-driven suppression of structural/immune mediators and activation of stress/remodeling pathways. | 4 | Li M (2026) | Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms. |
| Nicotinamide Skin Barrier Randomized Trial | Background Epithelial barrier disruption is a hallmark of allergic skin diseases. | 4 | Li M (2026) | Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms. |
| Nicotinamide Skin Barrier Randomized Trial | In conclusion, integrating skin barrier measurements with omics and machine learning enabled the dissection of essential anti-inflammatory and keratinocyte differentiation mechanisms and genes of a strengthened skin barrier. | 4 | Pat Y (2026) | Postbiotics and Nicotinamide Utilize Distinct Mechanisms to Improve Skin Barrier Integrity, Inflammation, and Keratinocyte Differentiation. |
| Nicotinamide Skin Barrier Randomized Trial | The modulation of immune responses and tissue regeneration by postbiotics is a rapidly advancing area in skin care. | 4 | Pat Y (2026) | Postbiotics and Nicotinamide Utilize Distinct Mechanisms to Improve Skin Barrier Integrity, Inflammation, and Keratinocyte Differentiation. |
| Nicotinamide Skin Barrier Randomized Trial | Here, we show that whole-cell postbiotics derived from Bifidobacterium breve, Limosilactobacillus reuteri, and Ligilactobacillus salivarius, along with nicotinamide (NAM), enhance keratinocyte growth, differentiation, and skin epithelial barrier integrity in ex vivo human skin, as determined by electrical impedance spectroscopy (EIS), multiomics, and machine learning. | 4 | Pat Y (2026) | Postbiotics and Nicotinamide Utilize Distinct Mechanisms to Improve Skin Barrier Integrity, Inflammation, and Keratinocyte Differentiation. |
Source documents