topicNiacinamide Skin Randomized Trial
claimAfter 112-day use of REGENMEDIC cream and serum, test group showed increased skin elasticity and firmness, reduced wrinkles, and an overall improvement in skin tone and texture.
evidence level2
citationLiu H (2026)
sourceSkin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study.
topicNiacinamide Skin Randomized Trial
claimPro-Xylane is a potent anti-aging ingredient; however, there is limited knowledge regarding whether a comprehensive post-procedure regimen incorporating a combination of Pro-Xylane, niacinamide, and panthenol alongside other active agents can deliver synergistic benefits for both skin barrier repair and anti-aging.
evidence level2
citationLiu H (2026)
sourceSkin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study.
topicNiacinamide Skin Randomized Trial
claimThis study assesses the effectiveness of the REGENMEDIC cream (anti-aging cream) and REGENMEDIC serum (anti-aging serum) in promoting skin barrier recovery and enhancing anti-aging effects following PicoWay laser treatment.
evidence level2
citationLiu H (2026)
sourceSkin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study.
topicNiacinamide Skin Randomized Trial
claimThe aim is to provide a mechanistically grounded and evidence‐oriented resource for researchers, dermatologists, and cosmetic scientists while distinguishing established clinical evidence from promising but still experimental approaches.
evidence level3
citationChen Yuanyuan (2026)
sourceAdvances in Skin Whitening Agents: Mechanisms, Clinical Applications, and Future Perspectives
topicNiacinamide Skin Randomized Trial
claimA third type, neuromelanin, is found in specific brain regions but has limited relevance to skin pigmentation [].
evidence level3
citationChen Yuanyuan (2026)
sourceAdvances in Skin Whitening Agents: Mechanisms, Clinical Applications, and Future Perspectives
topicNiacinamide Skin Randomized Trial
claimMITF Regulation by 32 33 34 35 36 37 Microphthalmia‐associated transcription factor (MITF) is a central regulator of melanocyte differentiation and melanogenic gene expression [].
evidence level3
citationChen Yuanyuan (2026)
sourceAdvances in Skin Whitening Agents: Mechanisms, Clinical Applications, and Future Perspectives
topicNiacinamide Skin Randomized Trial
claim1 2 Skin color is primarily determined by the amount, type, and distribution of melanin pigments in the epidermis.
evidence level3
citationChen Yuanyuan (2026)
sourceAdvances in Skin Whitening Agents: Mechanisms, Clinical Applications, and Future Perspectives