skin aging

Niacinamide Skin Barrier Randomized Trial Evidence Table

Structured evidence table for Niacinamide Skin Barrier Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Niacinamide Skin Barrier Randomized TrialAt the intrinsic level, aging results from genetically programmed physiological changes, including a decrease in the proliferative capacity of dermal fibroblasts, leading to reduced collagen and elastin production [].2Liu Huijuan (2026)Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study
Niacinamide Skin Barrier Randomized TrialDamage to this barrier disrupts its protective function, leading to increased susceptibility to irritants, pathogens, and dehydration, all of which contribute to premature aging [].2Liu Huijuan (2026)Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study
Niacinamide Skin Barrier Randomized TrialThis profile is particularly beneficial for Asian skin phototypes, as it significantly mitigates the risk of post-inflammatory hyperpigmentation while optimizing rejuvenation outcomes.2Liu Huijuan (2026)Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study
Niacinamide Skin Barrier Randomized Trial1 2 3 3 5 6 Skin aging is a complex biological process influenced by both intrinsic and extrinsic factors [].2Liu Huijuan (2026)Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study
Niacinamide Skin Barrier Randomized TrialBetula alba increased AQP3 and OCLN protein expression, something niacinamide was incapable of.4Smiljanic S (2022)<i>Betula alba</i> Bark Extract and <i>Empetrum nigrum</i> Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits.
Niacinamide Skin Barrier Randomized TrialIn conclusion, we identified a natural alternative to niacinamide for improving skin barrier health, in Scandinavian plant extracts, which yield strong performance, but at a lower concentration.4Smiljanic S (2022)<i>Betula alba</i> Bark Extract and <i>Empetrum nigrum</i> Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits.
Niacinamide Skin Barrier Randomized TrialThe aim of this study was to explore this natural diversity and identify plant extracts providing positive skin barrier effects.4Smiljanic S (2022)<i>Betula alba</i> Bark Extract and <i>Empetrum nigrum</i> Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits.
Niacinamide Skin Barrier Randomized TrialFollowing biochemical screening, two candidates outperformed the rest: Betula alba (BA) and Empetrum nigrum (EN).4Smiljanic S (2022)<i>Betula alba</i> Bark Extract and <i>Empetrum nigrum</i> Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits.
topicNiacinamide Skin Barrier Randomized Trial
claimAt the intrinsic level, aging results from genetically programmed physiological changes, including a decrease in the proliferative capacity of dermal fibroblasts, leading to reduced collagen and elastin production [].
evidence level2
citationLiu Huijuan (2026)
sourceSkin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study
topicNiacinamide Skin Barrier Randomized Trial
claimDamage to this barrier disrupts its protective function, leading to increased susceptibility to irritants, pathogens, and dehydration, all of which contribute to premature aging [].
evidence level2
citationLiu Huijuan (2026)
sourceSkin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study
topicNiacinamide Skin Barrier Randomized Trial
claimThis profile is particularly beneficial for Asian skin phototypes, as it significantly mitigates the risk of post-inflammatory hyperpigmentation while optimizing rejuvenation outcomes.
evidence level2
citationLiu Huijuan (2026)
sourceSkin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study
topicNiacinamide Skin Barrier Randomized Trial
claim1 2 3 3 5 6 Skin aging is a complex biological process influenced by both intrinsic and extrinsic factors [].
evidence level2
citationLiu Huijuan (2026)
sourceSkin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study
topicNiacinamide Skin Barrier Randomized Trial
claimBetula alba increased AQP3 and OCLN protein expression, something niacinamide was incapable of.
evidence level4
citationSmiljanic S (2022)
source<i>Betula alba</i> Bark Extract and <i>Empetrum nigrum</i> Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits.
topicNiacinamide Skin Barrier Randomized Trial
claimIn conclusion, we identified a natural alternative to niacinamide for improving skin barrier health, in Scandinavian plant extracts, which yield strong performance, but at a lower concentration.
evidence level4
citationSmiljanic S (2022)
source<i>Betula alba</i> Bark Extract and <i>Empetrum nigrum</i> Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits.
topicNiacinamide Skin Barrier Randomized Trial
claimThe aim of this study was to explore this natural diversity and identify plant extracts providing positive skin barrier effects.
evidence level4
citationSmiljanic S (2022)
source<i>Betula alba</i> Bark Extract and <i>Empetrum nigrum</i> Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits.
topicNiacinamide Skin Barrier Randomized Trial
claimFollowing biochemical screening, two candidates outperformed the rest: Betula alba (BA) and Empetrum nigrum (EN).
evidence level4
citationSmiljanic S (2022)
source<i>Betula alba</i> Bark Extract and <i>Empetrum nigrum</i> Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits.

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Source documents

  1. Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study
  2. <i>Betula alba</i> Bark Extract and <i>Empetrum nigrum</i> Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits.