topicNattokinase Blood Pressure Meta-Analysis
claimIn order to reduce the risk of thrombosis, patients with atherosclerotic cardiovascular disease are often prescribed antiplatelet therapy.
evidence level3
citationDobre Maria-Zinaida (2025)
sourceNavigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks
topicNattokinase Blood Pressure Meta-Analysis
claimNevertheless, platelet aggregation inhibition can also result in an increased bleeding risk, which is why the clinical approach must consider the benefit of single or dual antiplatelet treatments.
evidence level3
citationDobre Maria-Zinaida (2025)
sourceNavigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks
topicNattokinase Blood Pressure Meta-Analysis
claimThe bleeding risk in atherosclerosis can arise from plaque rupture or the presence of intraplaque hemorrhage.
evidence level3
citationDobre Maria-Zinaida (2025)
sourceNavigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks
topicNattokinase Blood Pressure Meta-Analysis
claim1 2 3 The development of atherosclerosis, an essential promoter of cardiovascular diseases and stroke via thrombus formation [], is supported by the interplay between platelets and endothelial cells [].
evidence level3
citationDobre Maria-Zinaida (2025)
sourceNavigating the Effects of Anti-Atherosclerotic Supplements and Acknowledging Associated Bleeding Risks
topicNattokinase Blood Pressure Meta-Analysis
claimFamilial hypercholesterolemia is due to LDLR, PCSK9, and APOB gene mutations that cause LDL clearance disorders, and ultimately LDL-C is significantly increased; familial mixed hyperlipidemia is a polygenic inheritance that leads to an increase in LDL and VLDL levels in the body, resulting in excessive TC and TG levels.
evidence level3
citationWei Chuyang (2025)
sourceResearch Progress of Nattokinase in Reducing Blood Lipid
topicNattokinase Blood Pressure Meta-Analysis
claimIn addition, it may also improve vascular endothelial function by inhibiting inflammatory factors such as TNF-α and IL-6, and indirectly reduce the risk of thrombosis.
evidence level3
citationWei Chuyang (2025)
sourceResearch Progress of Nattokinase in Reducing Blood Lipid
topicNattokinase Blood Pressure Meta-Analysis
claimDuring the NK purification process, the traditional protein expression and purification technology were changed and improved for better activity, but the results were less useful [].
evidence level3
citationWei Chuyang (2025)
sourceResearch Progress of Nattokinase in Reducing Blood Lipid
topicNattokinase Blood Pressure Meta-Analysis
claimAccording to the World Health Organization, about 18 million people die of CVD every year, accounting for more than 30% of all deaths worldwide [].
evidence level3
citationWei Chuyang (2025)
sourceResearch Progress of Nattokinase in Reducing Blood Lipid