evidence table

NAC Respiratory Randomized Trial Evidence Table

Structured evidence table for NAC Respiratory Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
NAC Respiratory Randomized TrialResults Patients treated with NAC nano-spray demonstrated a significant reduction in WHO mucositis grades and significantly improved OHIP-14 scores compared with the control group (p Conclusions N-acetylcysteine nano-spray appears to be an effective therapeutic option for the management of RIOM, reducing mucositis severity and improving quality of life in oral cancer patients.2Essam A (2026)N-acetylcysteine nano-spray versus conventional treatment in the management of radiotherapy-induced oral mucositis in oral cancer patients: a randomized clinical trial.
NAC Respiratory Randomized TrialBackground Radiation-induced oral mucositis (RIOM) is a common and debilitating complication of radiotherapy in oral cancer patients, significantly impairing quality of life and potentially interrupting treatment.2Essam A (2026)N-acetylcysteine nano-spray versus conventional treatment in the management of radiotherapy-induced oral mucositis in oral cancer patients: a randomized clinical trial.
NAC Respiratory Randomized TrialThis study evaluated the therapeutic efficacy of N-acetylcysteine (NAC) nano-spray in managing RIOM, with particular emphasis on mucositis severity, quality of life, and serum gastrin-17 levels.2Essam A (2026)N-acetylcysteine nano-spray versus conventional treatment in the management of radiotherapy-induced oral mucositis in oral cancer patients: a randomized clinical trial.
NAC Respiratory Randomized TrialClinically, it is the standard antidote for acetaminophen (APAP) overdose, restoring hepatic glutathione (GSH) and preventing or mitigating drug-induced liver injury and lowering risk of acute liver failure when administered within the ideal time window.It is also approved as a mucolytic in respiratory disease.3Qu Hui-Qi (2026)Redefining the role of the thiol-based agent N -acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative
NAC Respiratory Randomized TrialIn this review, these indicators are used only to illustrate the scale and diversification of NAC-related research activity, whereas assessment of therapeutic relevance rests primarily on mechanistic evidence and clinical studies.3Qu Hui-Qi (2026)Redefining the role of the thiol-based agent N -acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative
NAC Respiratory Randomized TrialClinical evidence is evaluated across major disease domains, including pulmonary and hepatic disorders, neuropsychiatric and neurodegenerative conditions, cardiometabolic disease, and oncology, with emphasis on sources of heterogeneity and opportunities for biomarker-guided stratification.3Qu Hui-Qi (2026)Redefining the role of the thiol-based agent N -acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative
NAC Respiratory Randomized TrialN 1,2 1 -Acetylcysteine (NAC) straddles two distinct roles: as an established therapeutic agent and as a dietary supplement.3Qu Hui-Qi (2026)Redefining the role of the thiol-based agent N -acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative
topicNAC Respiratory Randomized Trial
claimResults Patients treated with NAC nano-spray demonstrated a significant reduction in WHO mucositis grades and significantly improved OHIP-14 scores compared with the control group (p Conclusions N-acetylcysteine nano-spray appears to be an effective therapeutic option for the management of RIOM, reducing mucositis severity and improving quality of life in oral cancer patients.
evidence level2
citationEssam A (2026)
sourceN-acetylcysteine nano-spray versus conventional treatment in the management of radiotherapy-induced oral mucositis in oral cancer patients: a randomized clinical trial.
topicNAC Respiratory Randomized Trial
claimBackground Radiation-induced oral mucositis (RIOM) is a common and debilitating complication of radiotherapy in oral cancer patients, significantly impairing quality of life and potentially interrupting treatment.
evidence level2
citationEssam A (2026)
sourceN-acetylcysteine nano-spray versus conventional treatment in the management of radiotherapy-induced oral mucositis in oral cancer patients: a randomized clinical trial.
topicNAC Respiratory Randomized Trial
claimThis study evaluated the therapeutic efficacy of N-acetylcysteine (NAC) nano-spray in managing RIOM, with particular emphasis on mucositis severity, quality of life, and serum gastrin-17 levels.
evidence level2
citationEssam A (2026)
sourceN-acetylcysteine nano-spray versus conventional treatment in the management of radiotherapy-induced oral mucositis in oral cancer patients: a randomized clinical trial.
topicNAC Respiratory Randomized Trial
claimClinically, it is the standard antidote for acetaminophen (APAP) overdose, restoring hepatic glutathione (GSH) and preventing or mitigating drug-induced liver injury and lowering risk of acute liver failure when administered within the ideal time window.It is also approved as a mucolytic in respiratory disease.
evidence level3
citationQu Hui-Qi (2026)
sourceRedefining the role of the thiol-based agent N -acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative
topicNAC Respiratory Randomized Trial
claimIn this review, these indicators are used only to illustrate the scale and diversification of NAC-related research activity, whereas assessment of therapeutic relevance rests primarily on mechanistic evidence and clinical studies.
evidence level3
citationQu Hui-Qi (2026)
sourceRedefining the role of the thiol-based agent N -acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative
topicNAC Respiratory Randomized Trial
claimClinical evidence is evaluated across major disease domains, including pulmonary and hepatic disorders, neuropsychiatric and neurodegenerative conditions, cardiometabolic disease, and oncology, with emphasis on sources of heterogeneity and opportunities for biomarker-guided stratification.
evidence level3
citationQu Hui-Qi (2026)
sourceRedefining the role of the thiol-based agent N -acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative
topicNAC Respiratory Randomized Trial
claimN 1,2 1 -Acetylcysteine (NAC) straddles two distinct roles: as an established therapeutic agent and as a dietary supplement.
evidence level3
citationQu Hui-Qi (2026)
sourceRedefining the role of the thiol-based agent N -acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative

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Source documents

  1. N-acetylcysteine nano-spray versus conventional treatment in the management of radiotherapy-induced oral mucositis in oral cancer patients: a randomized clinical trial.
  2. Redefining the role of the thiol-based agent N -acetylcysteine in human health and disease and elucidating potential advantages of its amide derivative