Nac Respiratory Infections Meta-Analysis Evidence Table

Structured evidence table for Nac Respiratory Infections Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Nac Respiratory Infections Meta-AnalysisCONCLUSION: Erdosteine 900 mg is most effective for improving lung function and reducing oxidative stress, while cineole is safer with a lower incidence of adverse reaction and acute exacerbation.1Zhao Y (2026)Efficacy and safety of mucolytic agents in patients with chronic obstructive pulmonary disease: a systematic review and network meta-analysis.
Nac Respiratory Infections Meta-AnalysisBACKGROUND: This study aimed to compare the efficacy and safety of different mucolytic agents in patients with COPD.1Zhao Y (2026)Efficacy and safety of mucolytic agents in patients with chronic obstructive pulmonary disease: a systematic review and network meta-analysis.
Nac Respiratory Infections Meta-AnalysisThe control groups received placebo, usual care, or a medication other than the intervention group.1Zhao Y (2026)Efficacy and safety of mucolytic agents in patients with chronic obstructive pulmonary disease: a systematic review and network meta-analysis.
Nac Respiratory Infections Meta-AnalysisDespite robust evidence, NAC remains underutilized; greater clinical integration requires clearer guideline recommendations and clinician awareness.2Barne Monica (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
Nac Respiratory Infections Meta-AnalysisThis review consolidates current evidence and expert consensus on NAC for clinical reference.2Barne Monica (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
Nac Respiratory Infections Meta-AnalysisThis reduces mucus viscosity and facilitates improved mucociliary clearance.Anti-inflammatory effect of NAC: NAC modulates NF-κB signaling and scavenges reactive oxygen species (ROS), reducing inflammatory activation.2Barne Monica (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
Nac Respiratory Infections Meta-Analysis1 2 Figure 1 3 4 5 6 7 12 N-acetylcysteine (NAC), an acetylated derivative of L-cysteine, serves as a precursor of glutathione (GSH), a key pulmonary antioxidant.2Barne Monica (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
topicNac Respiratory Infections Meta-Analysis
claimCONCLUSION: Erdosteine 900 mg is most effective for improving lung function and reducing oxidative stress, while cineole is safer with a lower incidence of adverse reaction and acute exacerbation.
evidence level1
citationZhao Y (2026)
sourceEfficacy and safety of mucolytic agents in patients with chronic obstructive pulmonary disease: a systematic review and network meta-analysis.
topicNac Respiratory Infections Meta-Analysis
claimBACKGROUND: This study aimed to compare the efficacy and safety of different mucolytic agents in patients with COPD.
evidence level1
citationZhao Y (2026)
sourceEfficacy and safety of mucolytic agents in patients with chronic obstructive pulmonary disease: a systematic review and network meta-analysis.
topicNac Respiratory Infections Meta-Analysis
claimThe control groups received placebo, usual care, or a medication other than the intervention group.
evidence level1
citationZhao Y (2026)
sourceEfficacy and safety of mucolytic agents in patients with chronic obstructive pulmonary disease: a systematic review and network meta-analysis.
topicNac Respiratory Infections Meta-Analysis
claimDespite robust evidence, NAC remains underutilized; greater clinical integration requires clearer guideline recommendations and clinician awareness.
evidence level2
citationBarne Monica (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
topicNac Respiratory Infections Meta-Analysis
claimThis review consolidates current evidence and expert consensus on NAC for clinical reference.
evidence level2
citationBarne Monica (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
topicNac Respiratory Infections Meta-Analysis
claimThis reduces mucus viscosity and facilitates improved mucociliary clearance.Anti-inflammatory effect of NAC: NAC modulates NF-κB signaling and scavenges reactive oxygen species (ROS), reducing inflammatory activation.
evidence level2
citationBarne Monica (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
topicNac Respiratory Infections Meta-Analysis
claim1 2 Figure 1 3 4 5 6 7 12 N-acetylcysteine (NAC), an acetylated derivative of L-cysteine, serves as a precursor of glutathione (GSH), a key pulmonary antioxidant.
evidence level2
citationBarne Monica (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)

Source documents

  1. Efficacy and safety of mucolytic agents in patients with chronic obstructive pulmonary disease: a systematic review and network meta-analysis.
  2. N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)