evidence table

N-Acetylcysteine Stress Meta-Analysis Evidence Table

Structured evidence table for N-Acetylcysteine Stress Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
N-Acetylcysteine Stress Meta-AnalysisConclusion Our meta-analysis indicates that N-acetylcysteine, when compared to placebo, does not demonstrate consistent efficacy in reducing the primary symptoms of AUD or PTSD in broad patient populations.1Ahmed MAE (2026)N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
N-Acetylcysteine Stress Meta-AnalysisIntroduction Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are thought to be significant global contributors to the burden of mental illness.1Ahmed MAE (2026)N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
N-Acetylcysteine Stress Meta-AnalysisAccording to recent WHO epidemiological estimates, 3.9% of people worldwide have experienced PTSD at some point in their lives; this number rises to roughly 5.6% among those who have experienced trauma.1Ahmed MAE (2026)N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
N-Acetylcysteine Stress Meta-AnalysisDespite robust evidence, NAC remains underutilized; greater clinical integration requires clearer guideline recommendations and clinician awareness.2Barne Monica (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
N-Acetylcysteine Stress Meta-AnalysisThis review consolidates current evidence and expert consensus on NAC for clinical reference.2Barne Monica (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
N-Acetylcysteine Stress Meta-AnalysisThis reduces mucus viscosity and facilitates improved mucociliary clearance.Anti-inflammatory effect of NAC: NAC modulates NF-κB signaling and scavenges reactive oxygen species (ROS), reducing inflammatory activation.2Barne Monica (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
N-Acetylcysteine Stress Meta-Analysis1 2 Figure 1 3 4 5 6 7 12 N-acetylcysteine (NAC), an acetylated derivative of L-cysteine, serves as a precursor of glutathione (GSH), a key pulmonary antioxidant.2Barne Monica (2026)N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
topicN-Acetylcysteine Stress Meta-Analysis
claimConclusion Our meta-analysis indicates that N-acetylcysteine, when compared to placebo, does not demonstrate consistent efficacy in reducing the primary symptoms of AUD or PTSD in broad patient populations.
evidence level1
citationAhmed MAE (2026)
sourceN-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
topicN-Acetylcysteine Stress Meta-Analysis
claimIntroduction Alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) are thought to be significant global contributors to the burden of mental illness.
evidence level1
citationAhmed MAE (2026)
sourceN-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
topicN-Acetylcysteine Stress Meta-Analysis
claimAccording to recent WHO epidemiological estimates, 3.9% of people worldwide have experienced PTSD at some point in their lives; this number rises to roughly 5.6% among those who have experienced trauma.
evidence level1
citationAhmed MAE (2026)
sourceN-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
topicN-Acetylcysteine Stress Meta-Analysis
claimDespite robust evidence, NAC remains underutilized; greater clinical integration requires clearer guideline recommendations and clinician awareness.
evidence level2
citationBarne Monica (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
topicN-Acetylcysteine Stress Meta-Analysis
claimThis review consolidates current evidence and expert consensus on NAC for clinical reference.
evidence level2
citationBarne Monica (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
topicN-Acetylcysteine Stress Meta-Analysis
claimThis reduces mucus viscosity and facilitates improved mucociliary clearance.Anti-inflammatory effect of NAC: NAC modulates NF-κB signaling and scavenges reactive oxygen species (ROS), reducing inflammatory activation.
evidence level2
citationBarne Monica (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)
topicN-Acetylcysteine Stress Meta-Analysis
claim1 2 Figure 1 3 4 5 6 7 12 N-acetylcysteine (NAC), an acetylated derivative of L-cysteine, serves as a precursor of glutathione (GSH), a key pulmonary antioxidant.
evidence level2
citationBarne Monica (2026)
sourceN-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)

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Source documents

  1. N-acetylcysteine for patients with alcohol use disorder, post-traumatic stress disorder, and their co-occurrence: a systematic review of placebo-controlled randomized trials.
  2. N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR)