Structured evidence table for N-Acetylcysteine Oxidative Stress Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| N-Acetylcysteine Oxidative Stress Randomized Trial | However, robust evidence from well-powered randomized controlled trials is lacking. | 2 | Okunade KS (2026) | A randomized controlled trial of N-acetylcysteine in the treatment of early-onset preeclampsia: Study Protocol. |
| N-Acetylcysteine Oxidative Stress Randomized Trial | Background Despite significant advancements in obstetric care, the incidence of preeclampsia remains a substantial public health challenge, and effective strategies to prevent the disease progression remain limited, particularly in low-resource settings. | 2 | Okunade KS (2026) | A randomized controlled trial of N-acetylcysteine in the treatment of early-onset preeclampsia: Study Protocol. |
| N-Acetylcysteine Oxidative Stress Randomized Trial | N-acetylcysteine (NAC), an antioxidant and glutathione precursor, has demonstrated anti-inflammatory and vasodilatory effects, making it a promising candidate for repurposing. | 2 | Okunade KS (2026) | A randomized controlled trial of N-acetylcysteine in the treatment of early-onset preeclampsia: Study Protocol. |
| N-Acetylcysteine Oxidative Stress Randomized Trial | 1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults (). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| N-Acetylcysteine Oxidative Stress Randomized Trial | 1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence (). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| N-Acetylcysteine Oxidative Stress Randomized Trial | Low circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| N-Acetylcysteine Oxidative Stress Randomized Trial | In this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials. | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
Source documents